Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
VA Office of Research and Development
This two-year study will determine if daily oral intake of lipoic acid will prove superior to placebo in reducing injury to the brain and maintaining mobility in progressive MS. Mobility will be assessed with the timed 25-foot walk test and 2-minute timed walk test as well as fall counts. Neuroprotection will be measured by the extent of brain volume loss seen on MRI.
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of progressive MS as defined by the study
Able to give informed consent and to adhere to study procedures.
Expanded Disability Status Scale (EDSS) 3.0 - 6.5: ambulatory for at least 20 meters without rest and use of bilateral aids (canes, crutches, walker) or better.
You may not be if
A self-reported medical or neurological problem other than MS that is a cause of progressive or fluctuating gait dysfunction
Unable to undergo MRI
Unable to follow directions in English as standardized scales are not all validated in other languages.
Current major disease or disorder other than MS (e.g., cancer, renal disease, end-stage cardiopulmonary disease, post-traumatic stress disorder, etc.) that may interfere with study procedures. Note: Stable abnormal laboratory values of no more than Grade 1 determined to not be of clinical significance to the primary treating physician for that condition may be permitted per local site investigator discretion.
Pregnant or breast-feeding.
Insulin-dependent diabetes or diabetes not controlled on oral diabetes medications.
Scheduled (every 3 months or more frequently) IV or oral steroids in the year prior to enrolment.
IV or oral steroids in the 60 days prior to enrolment.
Use of LA in the prior 2 years exceeding the equivalent of 1200mg daily for 3 months.
