Clinical Trials in Philadelphia

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A Clinical Trial to Evaluate the Safety and Immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39.3 gp151 CD4KO HIV Trimer mRNA Vaccines in Healthy, HIV-uninfected Adult Participants

NCT05217641

This is an open-label, multicenter, randomized phase 1 study to evaluate the safety and immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39.3 gp151 CD4KO HIV trimer mRNA. These trimers are based on the BG505 MD39 native-like trimer reported in Steichen et al. Immunity 2016. The primary hypothesis is that the BG505 MD39.3 soluble and membrane-bound trimer mRNA vaccines will be safe and well-tolerated among HIV-uninfected individuals and will elicit autologous neutralizing antibodies.

HIV Infections

National Institute of Allergy and Infectious Diseases (NIAID)108 participantsStarted Feb 2022

Birmingham, Alabama, United States • Los Angeles, California, United States • Boston, Massachusetts, United States +7 more locations

RECRUITINGPhase 2< 1 mile

Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases

NCT05029336

A subset of autoimmune diseases (ADs) in children and young adults are life-threatening and unresponsive to conventional treatments. In these patients, the delivery of high dose immunosuppressive therapy followed by autologous stem cell transplant (ASCT) offers a treatment strategy capable of purging the pathogenic, autoreactive immune system and an opportunity for "immune reset." This strategy has been used in adults across a myriad of indications with evidence for efficacy. This study proposes a pilot study to evaluate this therapeutic strategy in children and young adults with systemic sclerosis (SSc) and systemic lupus erythematosis (SLE), two potentially life threatening autoimmune diseases that may response to this therapeutic approach.

Systemic Lupus ErythematosusSystemic Sclerosis

Stephan Grupp MD PhD20 participantsStarted Mar 2026

Philadelphia, Pennsylvania, United States

A Clinical Trial to Evaluate the Safety and Immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39.3 gp151 CD4KO HIV Trimer mRNA Vaccines in Healthy, HIV-uninfected Adult Participants

Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases

Find Trials by Condition in Philadelphia

A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease

Open-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR Participants

Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United States

Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Enhancing Memory in CPT for PTSD

CART22 Alone or in Combination With huCART19 for ALL

Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances

Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

Remote Patient Monitoring for Chronic Hypertension During Pregnancy (REACH)

Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome

Phase 1b/2a Randomized Double-blind Study to Investigate Safety Tolerability PK PD Preliminary Efficacy of Oral Administration of SNIPR001 in Patients With Hematologic Malignancy Scheduled for Allogeneic Hematopoietic Stem-Cell Transplant Receiving FQ Prophylaxis & Harboring FQR Ecoli Pre-Transplant

SKB264 in Combination With Pembrolizumab in Subjects With Selected Solid Tumors

COVID-19 Study of Pharmacokinetics, Safety, Tolerability, and Efficacy of Intravenous Anti-Spike(s) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) for the Treatment of Pediatric Patients Hospitalized Due to COVID-19

Role of Aerobic Exercise to Modulate Cardiotoxicity in Long Term Cancer Survivors Exposed to Anthracycline Therapy

A Study of GSK5733584 in Combination With Anti-cancer Therapies for Advanced Solid Tumors

A Study to Learn About the Occurrence of ADHD in Adults With Mental Conditions and Their Quality of Life

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease