Evaluation of Immediate Versus Delayed Loading of Dental Implants With a Modified Surface

Exclusion Criteria

• •Presence of conditions requiring chronic routine prophylactic use of antibiotics (e.g., history of rheumatic heart disease, bacterial endocarditis, cardiac valvular anomalies, prosthetic joint replacements)
• •Medical conditions requiring prolonged use of steroids
• •History of leukocyte dysfunction and deficiencies
• •History of bleeding disorders
• •History of neoplastic disease requiring the use of chemotherapy
• •History of radiation therapy to the head and neck
• •Patients with history of renal failure
• •Patients with severe or uncontrolled metabolic bone disorders
• •Uncontrolled endocrine disorders
• •Physical handicaps that would interfere with the ability to perform adequate oral hygiene
• •Use of any investigational drug or device within the 30 day period immediately prior to implant surgery on study day 0
• •Alcoholism or drug abuse
• •Patients infected with HIV
• •Patients who smoke \>10 cigarettes per day or cigar equivalents, or who chew tobacco
• •Conditions or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, or unreliability
• •Local inflammation, including untreated periodontitis
• •Mucosal diseases such as erosive lichen planus
• •History of local irradiation therapy
• •Presence of osseous lesions
• •Unhealed extraction sites (less than 4 months post extraction of teeth in intended sites)
• •Bone surgery (bone grafts, guided tissue regeneration techniques for bone enhancement) prior to implant placement unless performed more than 6 months prior to implant placement and the site fully healed. Note: Minor bone enhancement using harvested bone from the implant site and a resorbable membrane is allowed at the time of implant placement
• •Patients requiring bone grafting at the surgical sites at the time of surgery.
• •Severe bruxing or clenching habits
• •Persistent intraoral infection
• •Lack of primary stability of one (or more) implant(s) at surgery. In this instance the patient must be withdrawn and the patient treated accordingly
• •Patients with inadequate oral hygiene or unmotivated for adequate home care