Clinical Trials in Ohio

Showing 4441-4460 of 20,938 trials

A Gene Hunting Study for Familial Papillary Thyroid Cancer

NCT02776969

The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.

Thyroid

Ohio State University Comprehensive Cancer Center1,200 participantsStarted Aug 1998

Columbus, Ohio, United States

TERMINATEDPhase 332 miles

Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer

NCT04458909

This phase III trial compares the effect of adding nivolumab to the usual chemotherapy (cisplatin or carboplatin with gemcitabine) versus standard chemotherapy alone in treating patients with nasopharyngeal cancer that has come back (recurrent) or spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, carboplatin, and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving nivolumab with the usual chemotherapy may work better than the standard chemotherapy alone in treating patients with nasopharyngeal cancer.

Metastatic Nasopharyngeal CarcinomaMetastatic Nasopharyngeal Keratinizing Squamous Cell CarcinomaMetastatic Nasopharyngeal Nonkeratinizing Carcinoma+8 more

National Cancer Institute (NCI)15 participantsStarted Dec 2020

Birmingham, Alabama, United States • Anchorage, Alaska, United States • Anchorage, Alaska, United States +322 more locations

A Gene Hunting Study for Familial Papillary Thyroid Cancer

Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer

Find Trials by Condition in Ohio

Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care

Hyperbaric Oxygen Brain Injury Treatment Trial

Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)

Efficacy and Safety of Four Doses of Cenerimod Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus

Expanded Access Protocol for Patients With Eosinophilic Esophagitis

Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis

MB-105 in Patients With CD5 Positive T-cell Lymphoma

A Study of Lenvatinib (MK-7902) in Pediatric Participants With Relapsed or Refractory Solid Malignancies (MK-7902-013/E7080)

LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

An Open-Label Extension Study of BPN14770 in Subjects With Fragile X Syndrome

Study of Selinexor in Combination With Backbone Treatments or Novel Therapies In Participants With Relapsed or Refractory (RR) Diffuse Large B-Cell Lymphoma (DLBCL)

Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients With Chronic Lymphocytic Leukemia ("PRO-SID" Study)

Identification of Predictors for Clinical Outcomes in Femoroacetabular Impingement Surgery

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal Seizures

A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis

A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab