Evaluation of the Bioequivalence of Sprinkle and Capsule Formulations of Lubiprostone, as Compared to Placebo

Inclusion Criteria

• •Either has medically-confirmed diagnosis of chronic constipation (per Rome III), or meets the diagnosis as confirmed using the Rome III constipation module questionnaire during the Screening period.
• •Is male or female, 18 or older years of age
• •Should be on stable dose of fiber supplement or a concomitant medication for the indication of lowering blood pressure