Clinical Trials in Ohio

Showing 2601-2620 of 17,983 trials

Microfabricated Microcatheter Advantages in Middle Meningeal Artery Embolization: an Early Experience at a Single Center

NCT07324551

The purpose of this study is to evaluate the function of matched pair Aristotle 14 Guidewire and Plato Microcatheter in MMA embolization treatment for chronic subdural hematoma compared to surgeon's preference

Chronic Subdural HematomaHemorrhage Brain

Ohio State University100 participantsStarted Nov 2025

Columbus, Ohio, United States

RECRUITINGPhase 432 miles

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

NCT06445946

This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) randomized to oral metformin versus injectable insulin. This study will determine if metformin is not inferior to insulin in reducing adverse pregnancy outcomes, is comparably safe for exposed individuals and children, and if patient-reported factors, including facilitators of and barriers to use, differ between metformin and insulin. A total of 1,572 pregnant individuals with GDM who need pharmacotherapy will be recruited at 20 U.S. sites using consistent treatment criteria to metformin versus insulin. Participants and their children will be followed through delivery to two years postpartum.

Gestational Diabetes MellitusPregnancy, High Risk

Ohio State University1,572 participantsStarted Aug 2024

Tuscaloosa, Alabama, United States • Los Angeles, California, United States • San Francisco, California, United States +18 more locations

Microfabricated Microcatheter Advantages in Middle Meningeal Artery Embolization: an Early Experience at a Single Center

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

Find Trials by Condition in Ohio

CD40-L Blockade for Prevention of Acute Graft-Versus-Host Disease

Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)

Anti-pneumococcal Vaccine Strategy in Patients With Chronic Lymphocytic Leukemia

First-in-Human, Phase I, Open-label, Multicenter, Dose Escalation Clinical Study

[18F]PI-2620 Phase 3 Histopathological Study

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

Biodesign® Otologic Repair Graft

Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)

Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GS-9716 as Monotherapy and in Combination With Anticancer Therapies in Adults With Solid Malignancies

A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

SEEG-Guided DBS for OCD

Conservative Surgery in Treating Patients With Low-Risk Stage IA2 or IB1 Cervical Cancer

A Study to Evaluate the Efficacy, Safety, and Tolerability of ASC30 Tablets in Participants With Type 2 Diabetes Mellitus

A Phase 1b Study of Budoprutug in Systemic Lupus Erythematosus (SLE)

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.