Clinical Trials in North Carolina

Showing 5381-5400 of 20,428 trials

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

NCT04875052

The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who have undergone anterior cruciate ligament reconstruction surgery (ACLR). The main objectives are to compare the effects of Standard rehabilitation vs. rehabilitation that includes whole body vibration (WBV) or local muscle vibration (LMV) on: * Quadriceps muscle function * Gait biomechanics linked to post-traumatic knee osteoarthritis development * Patient self-report outcomes * MRI indicators of knee joint health and muscle quality * Landing biomechanics linked to secondary ACL injury risk * Evidence-based return-to-physical-activity criteria Participants will be assigned to 1 of 3 groups (standard rehabilitation, standard rehabilitation + WBV, or standard rehabilitation + LMV) and will complete assessments of quadriceps function, gait biomechanics, landing biomechanics, functional ability, patient-report outcomes, and MRI 1, 6, and 12 months after ACLR. Researchers will compare the groups to see if vibration embedded in ACLR rehabilitation improves joint health outcomes.

Osteoarthritis, KneeAnterior Cruciate Ligament InjuriesPost-traumatic Osteoarthritis+1 more

University of North Carolina, Chapel Hill114 participantsStarted Jan 2021

Chapel Hill, North Carolina, United States • Chapel Hill, North Carolina, United States

TERMINATEDPhase 246 miles

A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Alopecia Areata

NCT05556265

The purpose of this study is to evaluate the efficacy of deucravacitinib versus placebo at Week 24 and safety and tolerability of deucravacitinib versus placebo in adults with alopecia areata.

Alopecia Areata

Bristol-Myers Squibb94 participantsStarted Nov 2022

Santa Monica, California, United States • New Haven, Connecticut, United States • Tampa, Florida, United States +25 more locations

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Alopecia Areata

Find Trials by Condition in North Carolina

Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System

Long Term Extension Trial of Setmelanotide

Global Utilization And Registry Database for Improved heArt preservatioN

ECMO Hemostatic Transfusions in Children

Evaluation of Oral ORIN1001 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Spatz3 Adjustable Balloon System® (Spatz3) Post Approval Study

Study of the Relay Pro® Thoracic Stent-Graft in Subjects With Traumatic Injury of the Descending Thoracic Aorta

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease

Study of a Respiratory Syncytial Virus Candidate Encapsulated in a Lipid Nanoparticle Based Formulation in Adults Aged 18 to 50 Years and 60 Years and Older

A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures

Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia

Multicenter Trial of Meditation and Health Education for Cardiometabolic Disease in Black Women

Double-blind, Randomized Trial of PRAX-628 in Adults With Focal Seizures to Evaluate Efficacy and Safety (POWER1)

MAGIC Ruxolitinib for aGVHD

Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer

Prospective Multi-Center Study of Short-Term Outcomes After Complex Cholecystectomy