Assessment of ANK-700 in Patients With Relapsing Remitting Multiple Sclerosis

Exclusion Criteria

• •Diagnosis of primary progressive MS or secondary progressive MS
• •Uncontrolled or significant medical conditions (including active infection or chronic hepatitis) which, in the opinion of the Investigator, preclude participation
• •Patients treated with glatiramer acetate, parenteral steroids or adrenocorticotropic hormone, β-interferon, plasma exchange within the 3 months prior to first dose
• •Patients treated with sphingosine-1-phospate receptor modulators such as fingolimod, ozanimod, or siponimod within 6 months prior to first dose
• •Patients treated with cytotoxic agents (including, but not limited to, cladribine, mitoxantrone, cyclophosphamide, azathioprine, and methotrexate), laquinimod, teriflunomide, or IV gamma globulin within 12 months prior to first dose
• •Patients treated with monoclonal antibody therapy (including natalizumab, daclizumab, rituximab, ofatumumab, and ocrelizumab) within 24 months prior to first dose
• •Patients previously treated with alemtuzumab, total lymphoid irradiation, mesenchymal stem cell or hematopoietic stem cell transplantation, or tolerance-inducing therapies for MS
• •Contraindication to or inability to undergo gadolinium-enhanced magnetic resonance imaging (MRI) scan
• •Use of any investigational drug or experimental procedure within previous 6 months that would interfere with the assessment of ANK-700
• •Patients who are pregnant or breastfeeding
• •Patients receiving any vaccination within 28 days prior to first dose
• •Patient does not agree to limit alcohol intake to 2 drink equivalents or less per day during the study