Clinical Trials in North Carolina

Showing 5401-5420 of 20,428 trials

RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases

NCT00538343

The purpose of this study is to determine whether RTA 744 is effective in the treatment of breast cancer that has metastasized to the brain.

Brain Metastases

Biogen14 participantsStarted Oct 2007

West Palm Beach, Florida, United States • Charlotte, North Carolina, United States • Durham, North Carolina, United States +4 more locations

COMPLETEDPhase 341 miles

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

NCT04456673

Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by * Annualized rate of acute moderate or severe COPD exacerbation (AECOPD) Secondary Objectives: To evaluate the effect of dupilumab administered every 2 weeks on * Pre-bronchodilator forced expiratory volume in 1 second (FEV1) over 12 weeks compared to placebo * Health related quality of life, assessed by the change from baseline to Week 52 in the St. George's Respiratory Questionnaire (SGRQ) * Pre-bronchodilator FEV1 over 52 weeks compared to placebo * Lung function assessments * Moderate and severe COPD exacerbations * To evaluate safety and tolerability * To evaluate dupilumab systemic exposure and incidence of antidrug antibodies (ADA)

Chronic Obstructive Pulmonary Disease

Sanofi935 participantsStarted Jul 2020

Cullman, Alabama, United States • Jasper, Alabama, United States • Scottsboro, Alabama, United States +331 more locations

RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Find Trials by Condition in North Carolina

Adherence to Otezla

Risk Factors and Biomarkers for Diagnosis and Treatment of EoE

Community-associated Highly-Resistant Enterobacterales

Animal Assisted Therapy in Pediatric Dentistry

Randomized Therapy In Status Epilepticus

Safety and Tolerability of M254 in Healthy Volunteers and Immune Thrombocytopenic Purpura (ITP) Patients

Trial of Magrolimab (Hu5F9-G4) in Combination With Rituximab or Rituximab + Chemotherapy in Participants With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

Modifiers of Disease Severity in Cerebral Cavernous Malformations

A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain

Safety and Efficacy of Tideglusib in Congenital or Childhood Onset Myotonic Dystrophy

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy

An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism

Flexiva Pulse Registry

RTA 402 in Patients With Advanced Solid Tumors or Lymphoid Malignancies

Compound 31543 (Calcitriol, USP) in Patients Receiving Taxane-based Chemotherapy Regimens for the Treatment of Chemotherapy-Induced Alopecia

A Safety and Immune Response Study to Evaluate Varying Doses of an mRNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Healthy Adults