Clinical Trials in Cleveland

Showing 3841-3860 of 15,050 trials

Hydroxyurea Optimization Through Precision Study

NCT03789591

Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for children with SCA. The primary objective of the study is to evaluate whether a pharmacokinetics-based starting hydroxyurea dose thieves superior fetal hemoglobin response to to standard weight-based initial dosing. Patients will be recruited from the pediatric sickle cell clinic at Cincinnati Children's Hospital Medical Center and from additional pediatric sickle cell centers within the United States.

Sickle Cell DiseaseSickle Cell Anemia

Lifespan104 participantsStarted Jan 2019

Phoenix, Arizona, United States • Atlanta, Georgia, United States • Peoria, Illinois, United States +10 more locations

RECRUITING< 1 mile

Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study

NCT05811312

This study aims to assess how use of spinal cord stimulation for the treatment of chronic pain impacts brain structure and function. The investigators will use a non-invasive neuroimaging technique called resting state Near Infrared Spectroscopy and Electroencephalography (rs-fNIRS/EEG). The investigators will enroll Veterans who are currently receiving care at the Medical Center and who are either long term users of SCS for the treatment of their chronic pain or being evaluated for use of SCS to treat their pain.

Neuropathic Pain

VA Office of Research and Development40 participantsStarted Jul 2023

Cleveland, Ohio, United States

Hydroxyurea Optimization Through Precision Study

Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study

Find Trials by Condition in Cleveland

A Study for Kidney Transplant Recipients at High-Risk of Cytomegalovirus Infection

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

Phase Ib First in Human Dose Escalation of GT103 in Refractory, Advanced Stage Non-Small Cell Lung Cancer (TOP 1902)

REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study

Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples

Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry

Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer

The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Multi-Center Adolescent Clavicle Fracture Trial: Operative vs. Non-Operative Treatment

Study of AZD0466 Monotherapy or in Combination in Patients With Advanced Haematological Malignancies

Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies

Saroglitazar Magnesium for Treatment of Primary Biliary Cholangitis

G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study

Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy

A Study of TAK-079 in Adults With Persistent/Chronic Primary Immune Thrombocytopenia

EluPro Antibiotic-Eluting BioEnvelope Registry

Neoadjuvant And Adjuvant Abiraterone Acetate + Apalutamide Prostate Cancer Undergoing Prostatectomy