Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Exclusion Criteria

• •Donor age \<18 or \>85 years
• •Anticipated cold ischemia \>15 hours
• •Macrosteatosis \>40%
• •Terminal ALT \>1500 IU/ml
• •Peak ALT within 3 days \>3000 IU/ml
• •Terminal total bilirubin \>4 mg/dl
• •Presence of hemodynamic and/or anatomical donor abnormalities that, in the opinion of the Investigator, make the liver allograft unsuitable for transplant into the recipient subject
• •Liver intended for split transplant
• •Liver from living donor
• •Donor terminal serum Na \>160 mmol/L
• •Presence of hemodynamic and/or anatomical donor abnormalities that, in the opinion of the Investigator, make the liver allograft unsuitable for transplant into the recipient subject
• •Liver intended for split transplant
• •Liver from living donor
• •Donor terminal serum Na \>160 mmol/L
• •Subject will undergo multiple organ transplantations (liver-kidney, liver-lung, etc.)
• •Subject is listed for liver transplantation due to fulminant liver failure (UNOS status 1A)
• •Subject is pregnant
• •Subject is on respiratory (ventilator dependent) and/or cardiocirculatory support (requires at least one intravenous inotrope to maintain hemodynamics)
• •Subject is enrolled in an interventional clinical trial with an investigational drug or device