Clinical Trials in Boston

Showing 1161-1180 of 8,503 trials

Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN

NCT03613532

This clinical trial involves individuals who have been diagnosed with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), or MDS/myeloproliferative neoplasm-unclassifiable (MDS/MPN-unclassifiable) and are planning to have an allogeneic hematopoietic stem cell transplant ("bone marrow transplant"). The goal of this research study is to (1) test the safety of adding the study drug, Venetoclax, to a standard of care conditioning regimen for bone marrow transplantation as a possible means of eliminating residual (left-over) disease prior to transplant, (2) to test the safety of combination Venetoclax and azacitidine as "maintenance therapy" after transplant to possibly prevent disease recurrence and (3) to test the safety of combination Venetoclax and oral decitabine/cedazuridine as "maintenance therapy" after transplant to possibly prevent disease recurrence. * The name of the study drug involved in this study is Venetoclax. * It is expected that about 102 people will take part in this research study.

Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+2 more

Jacqueline Garcia, MD102 participantsStarted Oct 2018

Boston, Massachusetts, United States

TERMINATEDPhase 1< 1 mile

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

NCT04294160

A phase Ib, open-label platform study of select drug combinations chosen in order to characterize safety and tolerability of each treatment arm tested and to identify recommended doses and regimens for future studies.

BRAF V600 Colorectal Cancer

Novartis Pharmaceuticals122 participantsStarted Jul 2020

Los Angeles, California, United States • Boston, Massachusetts, United States • Nashville, Tennessee, United States +15 more locations

Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN

A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer

Find Trials by Condition in Boston

Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD

Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

Let's Know!2: Language-focused Intervention for Children at Risk of Comprehension Difficulties

Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease

Brain Health Program for Older Adults With Subjective Cognitive Decline

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

A Study of YL242 in Subjects With Advanced Solid Tumors

PET Imaging Evaluation of [11C]SY08

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age

Real-World Study of ABBV-951 Subcutaneous Infusion to Assess Change in Disease Activity in Adult Participants With Parkinson's Disease

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)

Safety and Efficacy of Nonacog Beta Pegol (N9-GP) in Previously Untreated Patients With Haemophilia B

Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Previously Untreated Patients With Haemophilia A

An Observational Study of Patients With Moderate Parkinson's Disease

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Clinical and Molecular Studies in Families With Inherited Eye Disease

AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.