Clinical Trials in Boston

Showing 9401-9420 of 17,836 trials

A Study to Assess the Safety and Efficacy of Secukinumab in Alleviating Symptoms of Discoid Lupus Erythematosus

NCT03866317

Discoid lupus erythematosus is a chronic inflammatory skin condition and may lead to itch, skin pain, open sores, scarring, disfigurement and hair loss. Studies have shown that IL-17A may play a major role in inflammation and in the pathogenesis of discoid lupus. Treatment of discoid lupus sometimes is a challenge and unresponsive to current therapies. Secukinumab, an anti-IL-17A monoclonal antibody has been safe and effective in the treatment of psoriasis. The investigators propose to study the efficacy and safety of secukinumab in discoid lupus.

Discoid Lupus Erythematosus

Massachusetts General HospitalStarted Sep 2019

Boston, Massachusetts, United States

WITHDRAWNPhase 1/2< 1 mile

Study to Assess Sarilumab in Halting Progression of Morphea

NCT03679845

An open-label single center trial studying the efficacy and safety of sarilumab on morphea patients.

Morphea, Plaque Form

Massachusetts General HospitalStarted Sep 2019

Boston, Massachusetts, United States

COMPLETED< 1 mile

COVID-19 and Mental Health

NCT04407195

The overall objective of this study is to assess the enormity of mental health outcomes among healthcare providers (nurses and physicians) exposed to COVID-19 during the time of the pandemic in the United States, specifically targeting those areas most effected.

COVID-19Mental Health Disorder

Northeastern University400 participantsStarted Jun 2020

Boston, Massachusetts, United States

UNKNOWNNA< 1 mile

GARNET™ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection

NCT04658017

To evaluate the feasibility of performing combined hemodialysis with the GARNET device in chronic hemodialysis patients with a blood stream infection (BSI), and measure clinical performance and safety endpoints.

Bloodstream Infection

Boa Biomedical, Inc.15 participantsStarted Mar 2021

Washington D.C., District of Columbia, United States • Baltimore, Maryland, United States • Bethesda, Maryland, United States +3 more locations

A Study to Assess the Safety and Efficacy of Secukinumab in Alleviating Symptoms of Discoid Lupus Erythematosus

Study to Assess Sarilumab in Halting Progression of Morphea

COVID-19 and Mental Health

GARNET™ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection

Find Trials by Condition in Boston

The Brain Stimulation and Physical Therapy Study

Study to Evaluate Switching From a Regimen of Two Nucleos(t)Ide Reverse Transcriptase Inhibitors (NRTI) Plus a Third Agent to a Fixed Dose Combination (FDC) of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF), in Virologically-Suppressed, HIV-1 Infected African American Participants

Inhaled Sedation in COVID-19-related Acute Respiratory Distress Syndrome (ISCA): an International Research Data Study in the Recent Context of Widespread Disease Resulting From the 2019 (SARS-CoV2) Coronavirus Pandemics (COVID-19)

Yttrium Y 90 Resin Microspheres Data Collection in Unresectable Liver Cancer: the RESIN Study

A Phase 1 Study Evaluating AMG 232 in Advanced Solid Tumors or Multiple Myeloma

221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease

Patients' Preferences About Rescheduling Colonoscopies Delayed Due to COVID-19: Cross Sectional Study

Clinical Study of Inhaled GB002 for Treatment of WHO Group I Pulmonary Arterial Hypertension

Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis

Psychological Intervention for Caregivers of Patients Undergoing Hematopoietic Stem Cell Transplantation (HCT)

Researching Emotions And Cardiac Health (REACH): Phase II

Identification/Characterization of Changes in Microscopic Colitis

Efficacy Study of Pharmacokinetic(PK)/Pharmacodynamic(PD) Relationship of Monotherapy MORAb-004 in Metastatic Melanoma

Talimogene Laherparepvec With Pembrolizumab for Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY232 / KEYNOTE-137)

An Extension Study to Assess the Long-Term Safety and Efficacy of Pasireotide in Participants With Acromegaly

Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)