Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis

Exclusion Criteria

• •Have severe extensive colitis as evidence by:
• •Physician judgment that the patient is likely to require colectomy or ileostomy within 12 weeks of baseline.
• •Current or recent (within 3 months) evidence of fulminant colitis, toxic megacolon, or bowel perforation.
• •Diagnosis of CD, indeterminate colitis, or the presence of fistula consistent with CD or microscopic colitis, radiation colitis, or ischemic colitis
• •Clinically relevant cardiovascular conditions or other relevant diseases that could impact the implementation or interpretation of the trial, or put the patient at risk
• •History of uveitis or unknown macular edema
• •Pregnancy, lactation, or a positive serum β-human chorionic gonadotropin (β-hCG) measured during screening