Clinical Trials in Boston

Showing 8881-8900 of 17,836 trials

Pharmacological Intervention for Symptomatic Mild Sleep Disordered Breathing

NCT04611750

Currently, there is no pharmacological intervention for mild symptomatic obstructive sleep disordered breathing (SDB) in the form of loud habitual snoring, inspiratory flow limitation (i.e. upper airway resistance syndrome), or mild sleep apnea. Here the investigators study the effect on SDB of stimulating pharyngeal muscles during sleep with AD036. The key hypothesis of the study is that AD036 is superior to placebo on self-reported and objective measures of SDB severity.

Sleep Disordered Breathing

Brigham and Women's Hospital53 participantsStarted Dec 2020

Boston, Massachusetts, United States • Clayton, Victoria, Australia

COMPLETEDPhase 3< 1 mile

Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients

NCT02851407

This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric patients undergoing hematopoietic stem cell transplant who are at high risk or very high risk of developing VOD.

Veno-occlusive Disease

Jazz Pharmaceuticals372 participantsStarted Sep 2016

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Tucson, Arizona, United States +111 more locations

Pharmacological Intervention for Symptomatic Mild Sleep Disordered Breathing

Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients

Find Trials by Condition in Boston

Zilver® PTX® V Clinical Study

Pre Bypass Ultrafiltration (PBUF) in Children Requiring Cardiopulmonary Bypass

Photobiomodulation to Improve Cognition in TBI, With fMRI

Mylan Insulin Aspart Study

A Pilot Study of BXCL701 in Patients With Pancreatic Cancer

PF-06651600 for the Treatment of Alopecia Areata

Feasibility and Efficacy of Physical Literacy Screening Integration Into Pediatric Clinical Settings

Study of ACY-1215 in Combination With Lenalidomide, and Dexamethasone in Multiple Myeloma

Study to Evaluate Safety and Efficacy of Dapagliflozin in Patients With Type 2 Diabetes Mellitus Aged 10-24 Years

Telmisartan Pilot Study on Treatment Resistant Schizophrenia

Study to Assess the Long Term Safety and Tolerability of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep

A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis

Extension Study Evaluating the Safety and Efficacy of Subcutaneous Tocilizumab (RoActemra/Actemra) Administration in Systemic and Polyarticular-Course Juvenile Idiopathic Arthritis

Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer

Eribulin Mesylate Administered in Combination With Gemcitabine Plus Cisplatin Versus Gemcitabine Plus Cisplatin Alone as First-Line Therapy for Locally Advanced or Metastatic Bladder Cancer

Safety and Efficacy of AMG 827 in Subjects With RA

SPI-2012 vs Pegfilgrastim in Management of Neutropenia in Breast Cancer Participants With Docetaxel and Cyclophosphamide

A Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis