Telmisartan Pilot Study on Treatment Resistant Schizophrenia

Exclusion Criteria

• •Psychiatrically unstable.
• •Subjects with any clinically significant abnormalities as determined by medical history, physical exam, clinical and lab evaluation suggestive of an underlying disease state that may, in the opinion of the investigator, confound the results of study, increase risk to the subject, or lead to difficulty complying with the study plan.
• •Current insulin treatment for diabetes.
• •History of immunosuppression.
• •Current or recent radiation or chemotherapy treatment for cancer.
• •Chronic use of steroids (except local use or inhaler).
• •Pregnancy or breastfeeding.
• •Women who are planning to become pregnant.
• •Use of diuretics, ACE inhibitors, spironolactone, potassium supplements, digoxin or warfarin because the possible drug-drug interaction with telmisartan.
• •Tested positive for the urine drug screen.
• •Subjects at imminent risk of suicide or injury to self or others, as per the opinion of the investigator, or history of significant suicide attempt within the last 6 months as per the Columbia Suicide Severity Rating Scale (C-SSRS).
• •Subjects that have taken an investigational drug or taken part in a clinical trial within 30 days prior to screening.
• •Subjects with a current (within the last 3 months) DSM-V diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine) as established by the clinical assessment (MINI) at the screening visit will be excluded.
• •Any other reason that, in the opinion of the investigator, would compromise patient safety or integrity of the study.
• •Subjects with the lab values defined as exclusionary safety values.