Clinical Trials in Boston

Showing 8701-8720 of 17,836 trials

Trial of PTK787/ZK 222584 Plus Paclitaxel

NCT00358163

PTK787/ZK 222584 is an inhibitor of VEGFR family tyrosine kinases. The primary objective of this study is to assess the safety of daily oral PTK787/ZK 222584 in combination with paclitaxel infused every 21 days. Secondary objectives include pharmacokinetic assessment of the impact of PTK787/ZK 222584 on paclitaxel metabolism and evaluation of tumor response to the investigational treatment.

Metastatic Non-hematologic Malignancies

Dana-Farber Cancer Institute7 participantsStarted Apr 2006

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States

COMPLETEDPhase 1< 1 mile

Topical Avastin for Treatment of Corneal Neovascularization

NCT00559936

The purpose of this study is to determine the effectiveness and safety of Topical Bevacizumab (Avastin) for treatment of corneal neovascularization.

Corneal Neovascularization

Massachusetts Eye and Ear Infirmary24 participantsStarted Feb 2007

Boston, Massachusetts, United States

COMPLETEDPhase 1/2< 1 mile

Evaluating the Safety and Immunogenicity of HIV Clade C DNA Vaccine and MF59- or AS01B-Adjuvanted Clade C Env Protein Vaccines in Various Combinations in Healthy, HIV-Uninfected Adults

NCT02915016

This study will evaluate the safety and immune response to the DNA-HIV-PT123 vaccine used in combination with one of two protein vaccines (Bivalent Subtype C gp120/MF59 or Bivalent Subtype C gp120/AS01B) in healthy, HIV-uninfected adults.

HIV Infections

National Institute of Allergy and Infectious Diseases (NIAID)334 participantsStarted Dec 2016

Birmingham, Alabama, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States +14 more locations

Trial of PTK787/ZK 222584 Plus Paclitaxel

Topical Avastin for Treatment of Corneal Neovascularization

Evaluating the Safety and Immunogenicity of HIV Clade C DNA Vaccine and MF59- or AS01B-Adjuvanted Clade C Env Protein Vaccines in Various Combinations in Healthy, HIV-Uninfected Adults

Find Trials by Condition in Boston

Development of a Next Generation Sequencing (NGS) -Based Assay to Detect Preeclampsia Molecular Markers

Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma

Decision Aid for Renal Therapy

Understanding Patient Experience and Preferences for the QT Scanner Compared to Mammography

CV301 Combined With PD-1/L1 Blockade in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer

Digital Narrative Bibliotherapy as a Scalable Intervention for Suicidal Thoughts

Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly With Vacuum Tube Holder

A Study Comparing the Efficacy of Pataday® Once Daily Relief Extra Strength to Claritin® Tablets 24-Hour in Subjects With Allergic Conjunctivitis

Yogurt Supplementation to Alter Bone Biomarkers, the Gut Microbiota and Inflammation in Older Adults

A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma

Study of Safety, Tolerability, and Efficacy of a Combination Treatment of LJN452 and CVC in Adult Patients With NASH and Liver Fibrosis

This Was a Dose-finding Study to Evaluate Efficacy and Safety of LOU064 in Patients With CSU Inadequately Controlled by H1-antihistamines

Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium

Improving Vision in Adults With Macular Degeneration

Steroid Sensitive Nephrotic Syndrome in Children

Study of the Safety and Pharmacokinetics of BGB-3111 in Subjects With B-Cell Lymphoid Malignancies

Trial of Vinflunine Plus Capecitabine in Advanced Breast Cancer