Clinical Trials in Boston

Showing 7861-7880 of 13,548 trials

Open Lung Strategy in Critically Ill Morbid Obese Patients

NCT02503241

The goal of this interventional crossover study in morbidly obese intubated and mechanically ventilated patients is to describe the respiratory mechanics and the heart-lung interaction at titrated positive end-expiratory pressure levels following a recruitment maneuver with transthoracic echocardiography and electric impedance tomography imaging.

ObesityRespiratory InsufficiencyRight-Sided Heart Failure+2 more

Massachusetts General Hospital21 participantsStarted Apr 2016

Boston, Massachusetts, United States

COMPLETEDPhase 1< 1 mile

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

NCT00031083

In this study an investigational replication-defective, recombinant adenovirus expressing the interferon-beta gene (BG00001) will be directly injected into tumors, in patients with recurrent Grade III and Grade IV Gliomas, in order to deliver the hIFN-beta gene. The purpose of the study is to evaluate the safety and any harmful effects of injection of BG00001 into brain tumors. Also, this study will help determine whether the virus carrying the beta interferon gene will enter brain tumor cells and cause the cancer cells to die. This study will require one hospital admission for the actual procedure of drug administration. All other visits will be conducted on an out-patient basis

Glioblastoma MultiformeAnaplastic AstrocytomaOligoastrocytoma, Mixed+1 more

Biogen12 participantsStarted Apr 2002

Birmingham, Alabama, United States • Tucson, Arizona, United States • Denver, Colorado, United States +2 more locations

Open Lung Strategy in Critically Ill Morbid Obese Patients

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Find Trials by Condition in Boston

Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc)

Safety and Efficacy of Switching From Dolutegravir and ABC/3TC or ABC/DTG/3TC to B/F/TAF in HIV-1 Infected Adults Who Are Virologically Suppressed

Integrating Online Weight Management With Primary Care Support

Mindful Self-Regulation fMRI Study (MindfulPCfMRI)

Stop-Service to Obviously-Impaired Patrons

Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum

Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye

A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)

The Effect of Screen Time on Recovery From Concussion

A Pragmatic Approach to Lowering the Risk of Diabetes Mellitus After A Diagnosis of Gestational Diabetes Mellitus

Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens

Quality of Life in Patients With Congenital Afibrinogenemia

A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy

Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome

Mobile Point of Care Diagnostic Testing for Ebola Virus Disease in DRC

Bone Mineral Density in Women With Uterine Fibroids or Endometriosis

Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Participants (DARWIN1)

To Document the Effectiveness of BoNT-A Injection in Adult Subjects With Upper Limb Spasticity Following Stroke