Clinical Trials in Boston

Showing 7861-7880 of 17,836 trials

Pilot Study of Motivational Interviewing for Loved Ones

NCT04010747

The study population for this research will include parents and concerned significant others (PCSO) of individuals experiencing recent (past five years) onset of a psychotic disorder (hereafter referred to as individuals with psychosis, "IP") who are not currently engaged with, or at risk for disengagement from, treatment. MILO is a brief and structured intervention that teaches motivational interviewing communication strategies. The initial aim (phase 1) of this pilot study is to evaluate feasibility of the intervention. The secondary aims are to evaluate the effectiveness of MILO for (1) enhancing the engagement of IP with evidence-based treatments and (2) reducing distress among PCSO. The investigators hypothesize that the intervention will be superior to control condition for both enhancing IP engagement with mental health services and reducing PCSO distress.

Psychotic DisordersPsychosisPsychotic Episode

Boston Medical Center71 participantsStarted Mar 2020

Boston, Massachusetts, United States

COMPLETEDPhase 2/3< 1 mile

A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS)

NCT04516096

The protocol is intended to provide extended treatment with AMX0035 to patients who previously participated in an Amylyx sponsored study of AMX0035 for ALS.

Amyotrophic Lateral Sclerosis

Amylyx Pharmaceuticals Inc.28 participantsStarted Nov 2020

San Francisco, California, United States • Boston, Massachusetts, United States • Worcester, Massachusetts, United States +2 more locations

Pilot Study of Motivational Interviewing for Loved Ones

A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS)

Find Trials by Condition in Boston

High Dose Chemotherapy and Stem Cell Transplant for Non-Hodgkin's Lymphoma or Central Nervous System (CNS) Lymphoma

Organizational Approaches to TWH for Low-Income Workers

Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic Purpura

An Investigational Immuno-therapy Study of Experimental Medication BMS-986179 Given Alone and in Combination With Nivolumab

Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors

A Study of Lanadelumab in Persons With Hereditary Angioedema (HAE) Type I or II in North America

Cerebral GABA and Fear Conditioning in PTSD

Cisplatin or Carboplatin, and Etoposide With or Without Sunitinib Malate in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Comparative Study of MCCE With/Without Tether vs Conventional Upper Endoscopy in Patients With Upper Abdominal Symptoms

Cognitive Strategies for Weight Loss

Positive Psychology for Physical Activity Promotion

Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory

Avelumab and Talazoparib in Untreated Advanced Ovarian Cancer (JAVELIN OVARIAN PARP 100)

IBD Neoplasia Surveillance Pilot RCT

Safety and Efficacy of Abaloparatide-SC in Men With Osteoporosis (ATOM)

GW572016 With Docetaxel and Trastuzumab for the Treatment Of Untreated ErbB2 Over-Expressing Metastatic Breast Cancer

Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis