Cerebral GABA and Fear Conditioning in PTSD

Exclusion Criteria

• •Medical condition that would confound results
• •history of seizures or head trauma with loss of consciousness
• •exposure to psychotropic medications within 4 weeks of study (8 weeks for fluoxetine)
• •metal implants, claustrophobia or other Magnetic Resonance Imaging (MRI) exclusions
• •positive urine toxicology or human chorionic gonadotropin (HCG) status on scan day
• •history of psychotic disorder, bipolar disorder, eating disorder, mental retardation, or pervasive developmental disorder; history of meeting full criteria for non-PTSD anxiety disorder.
• •PTSD and trauma subjects will be matched in terms of comorbid depressive disorder, not to exceed 50%. Trauma-exposed subjects will have a history of trauma exposure and will not meet criteria for PTSD. Non-traumatized healthy subjects will have no history of Axis I psychiatric disorder and no trauma exposure.