Clinical Trials in Boston

Showing 5661-5680 of 13,548 trials

Fulvestrant + Neratinib In Breast Cancer

NCT04901299

This is a Phase 2 open label, multi-center non-randomized interventional study designed to evaluate the safety and efficacy of combining Neratinib plus Fulvestrant in previously treated metastatic HR-positive, HER2-negative breast cancer. * This research study involves the study drug Neratinib * The standard of care drug Fulvestrant

Stage IV (Metastatic) Breast CancerMetastatic Breast CancerER Positive Breast Cancer+3 more

Massachusetts General HospitalStarted Jul 2023

Boston, Massachusetts, United States • Nashville, Tennessee, United States

UNKNOWN< 1 mile

EEG Monitoring in the Emergency Department

NCT04070521

This study seeks to investigate whether drug effects in suspected overdose patients could be identified using the electroencephalogram (EEG). From previous work it is known that different classes of anesthetic drugs have specific "EEG signatures" related to the drug mechanisms. Many of the drugs of abuse that are frequently encountered in overdose patients are similar or identical to anesthetic drugs. The hypothesis for this study is that the EEG could be used to characterize the brain effects of intoxicants using EEG in the ED setting. Such monitoring could one day help clinicians and first responders at the point-of-care make more informed decisions to improve the care of overdose patients.

Drug OverdoseSubstance AbuseAlcohol Abuse

Massachusetts General Hospital10 participantsStarted Sep 2019

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

A Text Message Intervention to Promote Health Behaviors in Cardiac Risk Conditions

NCT04382521

This is a randomized pilot trial to examine the feasibility, acceptability, and preliminary efficacy of an adaptive text message intervention (TMI) to promote well-being and health behavior adherence in 60 patients with two or more cardiac risk conditions (hypertension, type 2 diabetes, or hyperlipidemia).

HyperlipemiaHypertensionType2 Diabetes

Massachusetts General Hospital69 participantsStarted Sep 2020

Boston, Massachusetts, United States

Fulvestrant + Neratinib In Breast Cancer

EEG Monitoring in the Emergency Department

A Text Message Intervention to Promote Health Behaviors in Cardiac Risk Conditions

Find Trials by Condition in Boston

Replication of the EINSTEIN-PE Anticoagulant Trial in Healthcare Claims Data

Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (V114-029)

Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects

Replication of the HORIZON Pivotal Fracture Trial in Healthcare Claims Data

Replication of the TRITON-TIMI Antiplatelet Trial in Healthcare Claims Data

Replication of the PLATO Antiplatelet Trial in Healthcare Claims Data

Replication of the AMPLIFY Anticoagulant Trial in Healthcare Claims Data

Replication of the INSPIRE Trial in Healthcare Claims Data

Digital Fall Prevention Study

Replication of the RELY Anticoagulant Trial in Healthcare Claims Data

Replication of the DECLARE Diabetes Trial in Healthcare Claims

Optical Frequency Domain Imaging for Assessing Colonic Polyps

Groningen International Study on Sentinel Nodes in Vulvar Cancer-III

Reducing Veterans Hospitalizations From Community Living Centers

Real-World Evidence of Duration of Effect of Adhansia XR (Extended-Release) for Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD)

A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage (ES) Small Cell Lung Cancer (SCLC)

A Six-Month Follow-Up Study of Participants With Coronavirus Disease 2019 (COVID-19) Previously Enrolled in a RO7496998 (AT-527) Study