Clinical Trials in Boston

Showing 5101-5120 of 17,836 trials

Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea

NCT03189173

The current study combines two treatments for obstructive sleep apnea (OSA), oral appliances and supplemental inspired oxygen. The following aims will be tested: Aim 1. To determine whether supplemental inspired oxygen further reduces OSA severity (apnea-hypopnea index) in patients using an oral appliance. Aim 2. To determine whether baseline OSA phenotypes can predict the efficacy of oral appliances versus supplemental oxygen versus both treatments in combination. We will test whether responders to oral appliances have distinct pathophysiological characteristics compared with oxygen responders.

Obstructive Sleep Apnea

Brigham and Women's Hospital41 participantsStarted Sep 2017

Boston, Massachusetts, United States • Notting Hill, Victoria, Australia

Active Not RecruitingNA< 1 mile

Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends

NCT04865679

This pilot study evaluates the tolerability and feasibility of the Axoguard Large-Diameter Nerve Cap (sizes 5-7 mm) for protecting and preserving terminated nerve endings after limb trauma or amputation when immediate attention to the nerve injuries is not possible.

Symptomatic NeuromaAmputationChronic Nerve Pain

Axogen Corporation15 participantsStarted Mar 2022

Boston, Massachusetts, United States • Lubbock, Texas, United States

Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea

Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends

Find Trials by Condition in Boston

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

A Study Comparing Daratumumab, Lenalidomide, and Dexamethasone With Lenalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

Continued Access of Focal MR-Guided Focused Ultrasound for Localized Intermediate Risk Prostate Lesions

The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency

Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2

A Digital Intervention to Improve Physical Activity and Sleep Behaviors in Youth With Psychiatric Diagnoses

A Study of Copanlisib Combined With Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer

Imaging to Improve Brain Stimulation

Mechanisms of Perceptual Learning

Expanded Access for Cancer Treatment With Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884)

AltaValve Pivotal Trial

A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)

A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or II

HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients

Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea

An Investigation to Validate Speech Perception Assessment for Adult Cochlear Recipients Using a Mobile Research App