A Trial of LEE011 in Patients With Advanced Solid Tumors or Lymphoma.

Exclusion Criteria

• •1. Patients with primary central nervous system tumors or brain metastases. However, if radiation therapy and/or surgery has been completed and serial evaluation by CT (with contrast enhancement) or MRI over a minimum of 3 months demonstrates the disease to be stable and if the patient remains asymptomatic, then the patient may be enrolled. Such patients must have no need for treatment with steroids or anti-epileptic medications.
• •2. Impairment of gastro-intestinal (GI) function or GI disease that may significantly alter the absorption of LEE011 such as patients with a history of GI surgery which may result in intestinal blind loops and patients with clinically significant gastroparesis, unresolved nausea, vomiting, or diarrhea of CTCAE grade \> 1
• •3. Prior hematopoietic stem cell or bone marrow transplantation
• •4. Impaired cardiac function or clinically significant cardiac diseases, including any of the following:
• •* LVEF \<45% as determined by MUGA or echo
• •* Complete left bundle branch block
• •* Obligate use of a cardiac pacemaker or implantable cardioverter defibrillator
• •* Congenital long QT syndrome or family history of unexpected sudden cardiac death
• •* History or presence of ventricular tachyarrhythmia
• •* Presence of unstable atrial fibrillation (ventricular response \> 100 bpm
• •* Clinically significant resting bradycardia
• •* QTcF \>450 ms for males and \>470 ms for females on screening ECG
• •* Right bundle branch block and left anterior hemiblock (bifascicular block)
• •* Angina pectoris ≤ 3 months prior to dosing with study drug
• •* Acute MI ≤ 3 months prior to dosing with study drug
• •* Other clinically significant heart disease
• •5. Acute myocardial infarction or angina pectoris ≤ 3 months prior to starting study drug
• •6. Patients with concurrent severe and/or uncontrolled concurrent medical conditions that could compromise participation in the study (e.g. uncontrolled hypertension and/or diabetes mellitus, clinically significant pulmonary disease, clinically significant neurological disorder, active or uncontrolled infection).
• •Known diagnosis of HIV or hepatitis C