Clinical Trials in Boston

Showing 4781-4800 of 17,836 trials

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

NCT03675893

This research study is studying a combination of targeted therapies as a possible treatment for estrogen-receptor positive (ER+) endometrial cancer and low-grade serous ovarian cancer. The drugs involved in this study are: * Abemaciclib (also known as Verzenio™) * Letrozole (also known as Femara®) * Metformin (also known as Glucophage®) * Zotatifin (also known as eFT226) * Gedatolisib (also known as PF-05212384)

Endometrial CancerOvarian Cancer

Dana-Farber Cancer Institute180 participantsStarted Dec 2018

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States

Active Not RecruitingPhase 2< 1 mile

Multi-Center Study of ManNAc for GNE Myopathy

NCT04231266

GNE myopathy is a rare genetic muscle disease characterized by progressive muscle atrophy and weakness. The disease is caused by mutations in the gene that encodes the enzyme that initiates and regulates N-acetylneuraminic acid (Neu5Ac) biosynthesis and glycan sialylation. Currently, there is no therapy available for this disease. N-Acetylmannosamine (ManNAc), an orphan drug in development for GNE myopathy, is an uncharged monosaccharide and the first committed precursor in Neu5Ac biosynthesis. In this randomized, double-blind, placebo-controlled trial the efficacy and long-term safety of ManNAc will be evaluated in subjects with GNE myopathy.

GNE Myopathy

Leadiant Biosciences, Inc.54 participantsStarted Apr 2022

Los Angeles, California, United States • Iowa City, Iowa, United States • Kansas City, Kansas, United States +7 more locations

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Multi-Center Study of ManNAc for GNE Myopathy

Find Trials by Condition in Boston

Comprehensive HHT Outcomes Registry of the United States (CHORUS)

Neoadjuvant And Adjuvant Abiraterone Acetate + Apalutamide Prostate Cancer Undergoing Prostatectomy

Clinical Trial to Improve the Magnetic Levator Prosthesis

Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry

PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

Shared-Decision Making for Hydroxyurea

Genetics of Differences of Sex Development and Hypospadias

A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)

Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer

Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer

A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

A Study of Nivolumab or Placebo in Combination With Docetaxel in Men With Advanced Castration-resistant Prostate Cancer

A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

Inspiris Resilia Durability Registry

Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study

Evaluating Implementation and Impact of PeerOnCall, a Mobile Health Approach to Peer Support for Canadian Public Safety Personnel

Study of AZD0466 Monotherapy or in Combination in Patients With Advanced Haematological Malignancies

ColoCare Study - Colorectal Cancer Cohort