Finding studies
Finding studies
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Lead
AstraZeneca
The study consists of 2 individual modules as: Module 1 (AZD0466 monotherapy), and Module 2 (DDI study of AZD0466 with voriconazole). Eligible participants will be assigned to study treatments across Modules 1 and 2. 1. Module 1: AZD0466 monotherapy will include 2 parts- Part A dose escalation cohorts and Part B dose expansion cohorts. Initiation of Part B will depend on the evaluation of safety, tolerability, and PK in Part A. 2. Module 2: AZD0466 and voriconazole DDI study. All participants will receive AZD0466, and administration will continue until disease progression, initiation of alternative anticancer therapy, unacceptable toxicity, withdrawal of consent, or other reasons to discontinue study treatment.
Age
18–130
Sex
ALL
Healthy volunteers
Not accepted