Clinical Trials in Boston

Showing 4601-4620 of 17,836 trials

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

NCT03603808

This phase II trial studies the use of human papillomavirus (HPV) deoxyribonucleic acid (DNA) plasmids therapeutic vaccine VGX-3100 (VGX-3100) and electroporation in treating patients with human immunodeficiency virus (HIV)-positive high-grade anal lesions. Vaccines made from DNA may help the body build an effective immune response to kill tumor cells. Electroporation helps pores in your body's cells take in the drug to strengthen your immune system's response. Giving VGX-3100 and electroporation together may work better in treating patients with high-grade anal lesions.

Anal Intraepithelial NeoplasiaHigh Grade Squamous Intraepithelial NeoplasiaHIV Positivity+2 more

AIDS Malignancy Consortium35 participantsStarted Sep 2018

San Francisco, California, United States • Atlanta, Georgia, United States • Chicago, Illinois, United States +5 more locations

Active Not Recruiting< 1 mile

Long Term Follow Up for CTSN Mitral Valve Repair Studies

NCT03066050

This study is a continuation of two previous studies --- the Severe Ischemic Mitral Regurgitation (SMR) Trial (NCT00807040) and the Moderate Ischemic Mitral regurgitation (MMR) Trial (NCT00806988) --- to learn more about patients' health 5-10 years after their mitral valve surgeries. The investigators will collect long-term health information on SMR and MMR trial participants using electronic medical records, patient and/or family input, public records, and healthcare- and vital status-related databases.

Mitral Valve InsufficiencyCoronary Artery Disease

Icahn School of Medicine at Mount Sinai368 participantsStarted May 2017

Los Angeles, California, United States • Atlanta, Georgia, United States • Baltimore, Maryland, United States +21 more locations

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

Long Term Follow Up for CTSN Mitral Valve Repair Studies

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Ceramic-on-Ceramic (COC) 36mm Acetabular Bearing Insert Post Approval Study-New Subjects (COC36mmPAS)

Analysis of Surgery in Patients Presenting With Stage IV Breast Cancer

MMRC Horizon One Adaptive Platform Trial Evaluating Therapies in RRMM

Theranova 400 Dialyzer In End Stage Renal Disease (ESRD) Patients

Technology and Family Thriving Study

A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC)

A Study to Compare Nighttime Aligners to Daytime Aligners

Packaging and Disseminating the JOIN for ME Program in Low-Income Settings

A Dose-Escalation Study of SPYK04 in Patients With Locally Advanced or Metastatic Solid Tumors (With Expansion).

The Effect of Clinic Visit Audio Recordings for Self-management in Older Adults

A Study of mRNA-1018 Pandemic Influenza Candidate Vaccines in Healthy Adults

Etrasimod Versus Placebo for the Treatment of Moderately Active Ulcerative Colitis

A Multicenter Study Assessing the Efficacy and Safety of STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared With Vehicle in Subjects With Fuchs Endothelial Corneal Dystrophy (FECD)

A Study of Abemaciclib (LY2835219) Plus Hormone Therapy in Participants With Early Breast Cancer

A Study to Evaluate Effectiveness and Safety of Deucravacitinib in Participants With Non-Pustular Palmoplantar and Genital Psoriasis

A Study Evaluating Safety, Tolerability, and Clinical Activity of Forimtamig-Based Treatment Combinations in Participants With Relapsed or Refractory Multiple Myeloma

Performance Study of the Cobas® BV/CV Test on Samples From Participants With and Without Symptoms of Bacterial Vaginosis and Candida Vaginitis

Efficacy of [18F]PSMA-1007 PET/CT in Patients With Biochemial Recurrent Prostate Cancer