Clinical Trials in Boston

Showing 4301-4320 of 13,548 trials

School Inner-City Asthma Intervention Study (SICAS-2)

NCT02291302

The investigators goal is to determine the efficacy of school/classroom based environmental intervention in reducing asthma morbidity in urban schoolchildren.

Asthma

Boston Children's Hospital236 participantsStarted Jan 2015

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Using Non-Weightbearing Stationary Elliptical Machines for Patients with Chronic Low Back Pain

NCT05724160

The goal of this clinical trial is to assess the effect of non-weightbearing stationary ellipticals (Cubii, Fitness Cubed, Inc.) on patient well-being with chronic lower back pain (CLBP). The main questions it aims to answer are: 1. Assess the effect of non-weightbearing stationary ellipticals on clinical outcomes inclduing vital signs, pain, disability, analgesic use, mental health, abdominal muscle strength, and compliance in patients with CLBP. 2. Assess the effect of placing the patients into an interactive virtual environment during the exercise sessions on the outcomes of the program Participants will participate in 60 minute training sessions to see if there are effects to their CLBP.

Chronic Low-back PainLow Back Pain

Massachusetts General Hospital64 participantsStarted Sep 2023

Boston, Massachusetts, United States

RECRUITINGEARLY Phase 1< 1 mile

Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder

NCT06482762

The specific aim of this proposed study is to investigate the feasibility and therapeutic potential of transcranial focused ultrasound (tFUS) as a treatment for bipolar disorder (BD). Specifically, the investigators will study the effects of amygdala tFUS on corticolimbic activation during an emotion regulation task in BD, the effects of amygdala tFUS on corticolimbic resting-state functional connectivity in BD, and explore the relationship between tFUS-associated changes in amygdala activity and mood symptoms. The investigators hypothesize that transcranial focused ultrasound (tFUS) of the amygdala will be associated with decreased amygdala activation and increased ventromedial prefrontal cortex activation during a modified version of the Multi-Source Interference Task (MSIT) paired with affective pictures from the International Affective Picture System (IAPS). The investigators also hypothesize that tFUS of the amygdala will be associated with increased resting-state functional connectivity between the amygdala and ventromedial prefrontal cortex. Finally, the investigators hypothesize that tFUS-associated reductions in amygdala activity could be positively correlated with reductions in depressive symptom scores and global improvement.

Bipolar

Massachusetts General Hospital20 participantsStarted Jul 2024

Boston, Massachusetts, United States

School Inner-City Asthma Intervention Study (SICAS-2)

Using Non-Weightbearing Stationary Elliptical Machines for Patients with Chronic Low Back Pain

Low-Intensity Focused Ultrasound of the Amygdala for Bipolar Disorder

Find Trials by Condition in Boston

A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).

Promoting Informed Decisions About Cancer Screening in Older Adults

The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine

PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - S3 Intermediate

A Study of Sargramostim Plus Pembrolizumab with or Without Pemetrexed in Patients with Advance Non-small Cell Lung Cancer After Completion of Chemoimmunotherapy

STAMP+CBT mHealth for Cancer Pain

Open-Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis

The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring System (IPSS) Low Risk Myelodysplastic Syndrome (MDS)

Socializing a Science-Based Digital Therapeutic for Substance Use Disorders

AZD9291 (Osimertinib) Versus Platinum-Based Doublet-Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Talimogene Laherparepvec With Pembrolizumab in Melanoma Following Progression on Prior Anti-PD-1 Based Therapy (MASTERKEY-115) (Mk-3475-A07/KEYNOTE-A07).

EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)

Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease

Study of AMG 994 Monotherapy and AMG 994 and AMG 404 Combination Therapy in Participants With Advanced Solid Tumors

Study to Assess the Long-term Safety of Lenvatinib Monotherapy, a Lenvatinib Combination Regimen, or a Comparator Treatment Arm to Cancer Participants in Eisai Sponsored Lenvatinib Trials

Predictive Factors for Medullary Thyroid Cancer Aggressiveness

A Phase I/II Study of AZD0466 as Monotherapy or in Combination With Anticancer Agents in Advanced Non-Hodgkin Lymphoma