Oral Iron Repletion Effects On Oxygen Uptake in Heart Failure

Exclusion Criteria

• •1. Presence of a neuromuscular, orthopedic or other non-cardiac condition that prevents the patient from exercise testing on a bicycle/treadmill ergometer and/or inability to achieve an RER ≥ 1.0 on screening/baseline CPET
• •2. Severe renal dysfunction (eGFR\< 20 ml/min/1.73m2)
• •3. Severe liver disease (ALT or AST \> 3x normal, alkaline phosphatase or bilirubin \>2x normal)
• •4. Gastrointestinal conditions known to impair Fe absorption (i.e. inflammatory bowel disease)
• •5. Known active infection as defined by current use of oral or intravenous antimicrobial agents
• •6. Documented active gastrointestinal bleeding
• •7. Active malignancy other than non-melanoma skin cancers
• •8. Anemia with known cause other than Fe deficiency or chronic disease
• •9. Fe overload disorders (i.e. hemochromatosis or hemosiderosis)
• •10. History of erythropoietin, IV or oral Fe therapy, or blood transfusion in previous 3 months.
• •11. Current ventricular assist device
• •12. Anticipated cardiac transplantation within the next 4 months
• •13. Primary hypertrophic cardiomyopathy, infiltrative cardiomyopathy, acute myocarditis, constrictive pericarditis or tamponade
• •14. Previous adverse reaction to study drug or other oral Fe preparation
• •15. Known or anticipated pregnancy in the next 4 months