Clinical Trials in Boston

Showing 3881-3900 of 13,548 trials

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

NCT02974257

This study is to evaluate whether thiamine can increase oxygen consumption and lower lactate in patients who initially survive an in-hospital cardiac arrest. Patients who are successfully resuscitated after an in-hospital cardiac arrest and who are on mechanical ventilation in the intensive care unit will be enrolled, and will get either thiamine or placebo. Their oxygen consumption and lactate will be measured at serial time points and compared between groups. The investigators' hypothesis is that thiamine will help restore the body's ability to metabolize oxygen normally (aerobic metabolism), leading to an increase in oxygen consumption and a decrease in lactate.

Cardiac ArrestShockLactic Acidosis+1 more

Beth Israel Deaconess Medical Center41 participantsStarted May 2017

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System (SUMMIT MAX)

NCT05018650

The SUMMIT MAX study is a prospective, randomized, controlled, interventional clinical trial to evaluate the safety and effectiveness of the Route 92 Medical MonoPoint® Reperfusion System with the Hi Point 88 and HiPoint 70 Reperfusion Catheters for aspiration thrombectomy in acute ischemic stroke patients.

Acute Ischemic Stroke

Route 92 Medical, Inc.250 participantsStarted Dec 2021

Mesa, Arizona, United States • Carmichael, California, United States • Newark, Delaware, United States +27 more locations

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System (SUMMIT MAX)

Find Trials by Condition in Boston

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma

Study of Efficacy of CML-CP Patients Treated With ABL001 Versus Bosutinib, Previously Treated With 2 or More TKIs

REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma

Safety Study of XT-150 in Participants With ALS

Evaluating the Efficacy of Cranial Electrotherapy Stimulation in Mitigating Anxiety-induced Cognitive Deficits

Altering Multitasking Behavior Using Low Current Brain Stimulation

Regulation of Emotion, Sleep Extension, and mTBI

Y-90, Capecitabine, and Atezolizumab for Oligometastatic CRC

Study of the Adverse Events and Change in Disease State of Pediatric Participants (and Young Adults Between the Ages of 18-25) With Relapsed/Refractory Aggressive Mature B-cell Neoplasms Receiving Subcutaneous (SC) Injections of Epcoritamab

Tezepelumab Efficacy and Safety in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma

Assessment of Transcatheter Edge-to-Edge Repair in Atrial Functional Mitral Regurgitation (ATRIAL-MR)

Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy

Long Term Follow-up of HPV Vaccine in HIV (CTN 236)

Efficacy and Safety of Delgocitinib Cream in Adults With Moderate to Severe Chronic Hand Eczema (DELTA 2)

A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1 Antihistamines

Study to Evaluate the Efficacy of a Probiotic in Infantile Colic Symptoms Relief

Effect of Tusamitamab Ravtansine on QTc Interval in Participants With Metastatic Solid Tumors