Clinical Trials in Boston

Showing 3641-3660 of 11,609 trials

Safety and Clinical Activity of KT-253 in Adult Patients with High Grade Myeloid Malignancies, Acute Lymphocytic Leukemia, Lymphoma, Solid Tumors

NCT05775406

This Phase 1 study will evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics (PK/PD), and clinical activity of KT-253 in adult patients with relapsed or refractory (R/R) high grade myeloid malignancies, acute lymphocytic leukemia (ALL), R/R lymphoma, myelofibrosis, and R/R solid tumors. The study will identify the pharmacologically optimal dose(s) (MTD) of KT-253 as the recommended Phase 2 dose (RP2D), based on all safety, PK, PD, and efficacy data.

Myeloid MalignanciesAcute Lymphocytic LeukemiaLymphomas+1 more

Kymera Therapeutics, Inc.52 participantsStarted May 2023

Scottsdale, Arizona, United States • Sacramento, California, United States • Boston, Massachusetts, United States +8 more locations

Active Not RecruitingPhase 3< 1 mile

Treating Schizophrenia by Correcting Abnormal Brain Development

NCT00179465

The purpose of this study is to determine whether treatment with tiagabine (Gabitril) during the early course of schizophrenia can fundamentally correct the brain deficits associated with the disease. This study is funded by the National Institutes of Health.

Schizophrenia

Beth Israel Deaconess Medical Center36 participantsStarted Nov 2003

Boston, Massachusetts, United States

Safety and Clinical Activity of KT-253 in Adult Patients with High Grade Myeloid Malignancies, Acute Lymphocytic Leukemia, Lymphoma, Solid Tumors

Treating Schizophrenia by Correcting Abnormal Brain Development

Find Trials by Condition in Boston

A Randomized Controlled Trial of Leg Length Discrepancy Techniques

Transcatheter Aortic Valve Replacement (TAVR) Effects on Cardiac Conduction System

Self-Assembling Matrix Forming Gel to Prevent Stricture Formation

Pilot Study of Rosuvastatin and Enoxaparin Thromboprophylaxis Following Ovarian Cancer Surgery (O-STAT Study)

BOTOX Effects on Seizure Severity and Susceptibility

Novel Experimental COVID-19 Therapies Affecting Host Response

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

The Gilenya Pregnancy Registry

Efatutazone Dihydrochloride in Treating Patients With Previously Treated Myxoid Liposarcoma That Cannot Be Removed by Surgery

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Trastuzumab Deruxtecan With Nivolumab in Advanced Breast and Urothelial Cancer

Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)

A Study of Elecsys® Troponin T hs Gen 6 in Participants With Symptoms of Acute Coronary Syndrome

Trial of LAVA-051 in Patients with Relapsed/refractory CLL, MM, or AML

Intermediate-Size Expanded Access Protocol (EAP) for LP352

Extension to the MAGNIFY MS Trial on Mavenclad® (Magnify MS Extension)

Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation

International Treatment-extension Study in Adult Participants With Multiple Myeloma and Who Have Derived Clinical Benefit From Isatuximab