Clinical Trials in Boston

Showing 3001-3020 of 8,503 trials

AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program

NCT06079762

Aim 1: To assess the feasibility and acceptability of delivering AGE SELF CARE through virtual medical group visits by measuring recruitment rate, adherence, and participant satisfaction. Hypothesis 1: It will be feasible to recruit 12 older adults who are pre-frail. Hypothesis 2: At least 70% of participants will attend 6 of 8 group visit sessions. Hypothesis 3: At least 70% of participants will report satisfaction with the program. Aim 2: Determine the feasibility and burden of measuring frailty in this study by different instruments. Hypothesis 1: At least 70% of participants will complete portions of all frailty assessments. Hypothesis 2: Participants will not find testing to be burdensome and measures may be completed in 60 minutes or less. Hypothesis 3: Mean gait speed and frailty index will improve from baseline to post-intervention.

FrailtyAgingFrailty Syndrome+1 more

Brigham and Women's Hospital11 participantsStarted Oct 2023

Boston, Massachusetts, United States

COMPLETEDPhase 1< 1 mile

Safety, Tolerability, and Pharmacokinetic (PK) Study of DHES0815A in Participants With Human Epidermal Growth Factor Receptor (HER)2-Positive Breast Cancer

NCT03451162

This first-in-human, Phase 1, open-label, multicenter, dose-escalation study will evaluate the safety, tolerability, and PK of DHES0815A as a single agent in participants with advanced and/or metastatic HER2-positive breast cancer for whom established treatment has proven ineffective or intolerable or is unavailable. The study may include a dose-expansion cohort (based on an ongoing assessment of the totality of data obtained in this study) to further assess safety, tolerability, PK, and preliminary anti-tumor activity.

Breast Cancer

Genentech, Inc.14 participantsStarted Apr 2018

New Haven, Connecticut, United States • Boston, Massachusetts, United States • New York, New York, United States +2 more locations

AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program

Safety, Tolerability, and Pharmacokinetic (PK) Study of DHES0815A in Participants With Human Epidermal Growth Factor Receptor (HER)2-Positive Breast Cancer

Find Trials by Condition in Boston

Pilot Trial of Contingency Management for Long-Term Cannabis Abstinence

Effect of AT7519M Alone and AT7519M Plus Bortezomib in Patients With Previously Treated Multiple Myeloma

Improving Psychosocial Functioning in Older Veterans With PTSD

A Randomized Trial of Low-Dose Bevacizumab vs Laser for Type 1 ROP

ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI)

MCS110 With BRAF/MEK Inhibition in Patients With Melanoma

A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer

Exploratory Study on Effect of Whitening Agent With Emulsion Gel in Xerostomic Population

Evaluation of Efficacy, Safety of Vandetanib in Patients With Differentiated Thyroid Cancer

A Study of AT13387 in Patients With Non-Small Cell Lung Cancer (NSCLC) Alone and in Combination With Crizotinib

Study of VIB7734 for the Treatment of Moderate to Severely Active SLE

Episealer® Knee System IDE Clinical Study

Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)

Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma

Efficacy, Safety, and Tolerability of Gebasaxturev (V937) Administered Intravenously or Intratumorally With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone in Participants With Advanced/Metastatic Melanoma (V937-011)

Evaluation of Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis Subjects Without an F508del Mutation

Efficacy and Safety of Roxadustat for Treatment of Anemia in Participants With Lower Risk Myelodysplastic Syndrome With Low Red Blood Cell Transfusion Burden

A Study to Evaluate the Effectiveness and Safety of SKI-O-703 in Patients Experiencing Active Rheumatoid Arthritis Despite Treatment With Conventional Therapies.