Clinical Trials in Boston

Showing 2961-2980 of 17,836 trials

Wide Excision Alone as Treatment for Ductal Carcinoma in Situ of The Breast

NCT00165256

The purpose of this study is to determine if wide excision (surgical removal) alone is adequate treatment for small, grade 1 or 2 ductal carcinoma in situ (DCIS) of the breast.

Ductal Carcinoma in Situ of the Breast

Dana-Farber Cancer Institute158 participantsStarted May 1995

Boston, Massachusetts, United States • Boston, Massachusetts, United States

WITHDRAWNPhase 2< 1 mile

Zimberelimab + Domvanalimab in Gastroesophageal Adenocarcinoma

NCT07283848

The purpose of the study is to understand whether study drugs domvanalimab and zimberelimab are safe and effective in combination with standard chemotherapy for patients with operable cancer of the esophagus, stomach, or gastroesophageal junction (where the stomach meets the esophagus). All participants will receive the study treatment. Participants will receive chemotherapy and two immune therapies drugs (domvanalimab and zimberelimab) for up to 4 months before surgery. After surgery and at least a 4 week recovery, participants will receive domvanalimab and zimberelimab for up to 8 months. After completion of the study treatment, participants will be followed for up to 5 years per standard of care.

Adenocarcinoma StomachAdenocarcinoma Gastroesophageal Junction

Massachusetts General HospitalStarted Feb 2026

Boston, Massachusetts, United States

COMPLETED< 1 mile

Prevention of Colorectal Cancer Through Multiomics Blood Testing

NCT04369053

The PREEMPT CRC study is a prospective multi-center observational study to validate a blood-based test for the early detection of colorectal cancer by collecting blood samples from average-risk participants who will undergo a routine screening colonoscopy.

Colon CancerRectal CancerColon Neoplasm+8 more

Freenome Holdings Inc.48,995 participantsStarted May 2020

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Huntsville, Alabama, United States +145 more locations

Wide Excision Alone as Treatment for Ductal Carcinoma in Situ of The Breast

Zimberelimab + Domvanalimab in Gastroesophageal Adenocarcinoma

Prevention of Colorectal Cancer Through Multiomics Blood Testing

Find Trials by Condition in Boston

A Study of LY3039478 in Participants With Advanced Cancer

Community Collaboration to Advance Racial/Ethnic Equity in CRC Screening

Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT)

Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 1)

Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing

Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

A Study of YL242 in Subjects With Advanced Solid Tumors

Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease

Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst

An Immuno-therapy Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab or Nivolumab in Combination With Other Agents in Patients With Advanced Liver Cancer

Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age

The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults

Observational Study Protocol: LIVER-R

A Study to Evaluate the Safety, Pharmacokinetics, and Occurrence of Anti-Drug Antibodies Following Annual Doses of CD388