Clinical Trials in Boston

Showing 2781-2800 of 8,503 trials

MIRACLE of LIFE Study

NCT06074601

The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1. Can cell-free RNA-based biomarkers predict which pregnant people are at greatest risk of developing adverse pregnancy outcomes (e.g., preterm birth, preeclampsia)? 2. What is the performance of such biomarkers when predicting an adverse pregnancy outcome (e.g., sensitivity, specificity, PPV, NPV, TPR)?

Preterm LaborPreterm BirthPreterm Birth Complication+7 more

Mirvie10,000 participantsStarted Aug 2021

San Diego, California, United States • Orlando, Florida, United States • New Orleans, Louisiana, United States +7 more locations

COMPLETEDPhase 2< 1 mile

A Study of Abemaciclib (LY2835219) in Women With HR+, HER2+ Locally Advanced or Metastatic Breast Cancer

NCT02675231

The purpose of this study is to evaluate the effectiveness of abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus physicians choice standard of care chemotherapy in women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 positive (HER2+) locally advanced or metastatic breast cancer after prior exposure to at least two HER2-directed therapies for advanced disease.

Hormone Receptor Positive Breast CancerHER-2 Positive Breast Cancer

Eli Lilly and Company237 participantsStarted May 2016

Bakersfield, California, United States • Fullerton, California, United States • Los Angeles, California, United States +90 more locations

MIRACLE of LIFE Study

A Study of Abemaciclib (LY2835219) in Women With HR+, HER2+ Locally Advanced or Metastatic Breast Cancer

Find Trials by Condition in Boston

A Study of ZN-c3 in Patients With Ovarian Cancer

Working Memory Training for People Aging with HIV

A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

Digital Health Interventions for Obsessive Compulsive Disorder (OCD)

Analysis of Both Sex and Device Specific Factors on Outcomes in Patients with Non-Ischemic Cardiomyopathy

Glyburide Advantage in Malignant Edema and Stroke Pilot

Molecular Genetic Mechanisms of Infantile Epilepsies and the Impact of Genetic Diagnosis

Feasibility Study of the Reia Vaginal Pessary

A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes)

Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Older Adult Subjects With Overactive Bladder (OAB)

Real-World Evaluation of Eko Algorithms in a Point of Care Setting

FPA150 in Patients With Advanced Solid Tumors

Safety and Immunogenicity of RNA-based Vaccines Against SARS-CoV-2 Variants in Healthy Participants

Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor Receptor- (EGFR)-Mutated Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-789/KEYNOTE-789)

Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IF

A Gene Transfer Study for Late-Onset Pompe Disease (RESOLUTE)

Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System.

Adjunctive Fosfomycin for Treatment of Staphylococcus Aureus Bacteraemia