Clinical Trials in Boston

Showing 2681-2700 of 17,836 trials

Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE

NCT06310018

SONIC-PE is a multicenter, prospective, single-arm study of 10 patients with bilateral PE treated with ultrasound-facilitated, catheter-directed lower-dose fibrinolysis (total dose 8 mg tPA given as 2 mg/hour/catheter over 2 hours) followed by 50 patients (total dose 6 mg tPA given as 3 mg/hour/catheter given over 1 hour) with the EKOS+™ system to determine its impact on the change in RV-to-LV diameter, refined Modified Miller Score, and distal pulmonary vascular blood volume as well as to assess International Society on Thrombosis and Haemostasis (ISTH) major bleeding.

Pulmonary EmbolismRight Ventricular DysfunctionRight Ventricular Failure

Brigham and Women's Hospital60 participantsStarted Jan 2027

Boston, Massachusetts, United States

COMPLETED< 1 mile

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

NCT01374360

This study is a collection of data to evaluate safety and characterize progression of Paroxysmal Nocturnal Hemoglobinuria (PNH).

Paroxysmal Nocturnal Hemoglobinuria

Alexion Pharmaceuticals, Inc.6,061 participantsStarted Oct 2004

Boston, Massachusetts, United States

SUSPENDED< 1 mile

Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography

NCT06099275

The goal of this observational trial is to determine the resting cardiac output (CO) using transthoracic echocardiography (TTE) in a cohort of people with untreated preeclampsia, and a cohort of healthy normotensive pregnant people.

Preeclampsia

Brigham and Women's Hospital80 participantsStarted Oct 2026

Boston, Massachusetts, United States

Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography

Find Trials by Condition in Boston

Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Population: The INFORM Study

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

A Study Comparing Daratumumab, VELCADE (Bortezomib), Lenalidomide, and Dexamethasone (D-VRd) With VELCADE, Lenalidomide, and Dexamethasone (VRd) in Participants With Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

Losartan to Improve Outcomes After Multi-ligament Knee Injury

Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine

Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event

Study to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Evaluation of the Efficacy and Safety of Magnetic Resonance Angiography (MRA) Using Gadopiclenol Compared to Gadoterate Meglumine in the Assessment of Steno-occlusive Disease in Adult Patients With Suspected Vascular Disease

Expanded Access Protocol for Boys With Duchenne Muscular Dystrophy

Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia

A Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Participants With Cirrhosis-ZEAL-UNLOCK

Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants