Clinical Trials in Boston

Showing 2601-2620 of 8,503 trials

Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome

NCT02461420

The purpose of this study is to comprehensively characterize PMS using standardized medical, cognitive, and behavioral measures and to track the natural history of the syndrome using repeated longitudinal assessments. In addition, this study will be aiming to identify biomarkers using neuroimaging, including diffusion tensor imaging and identify genetic factors which contribute to diverse phenotypes in patients with PMS.

Phelan-McDermid SyndromeAutism Spectrum DisorderIntellectual Disability

Boston Children's Hospital205 participantsStarted May 2015

Stanford, California, United States • Chicago, Illinois, United States • Bethesda, Maryland, United States +2 more locations

TERMINATEDPhase 1/2< 1 mile

A Study of KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC)

NCT04718675

Part 1: Dose Escalation. The primary objective of Part 1 of this study is to evaluate the safety and tolerability of KB-0742 in participants with relapsed or refractory (R/R) solid tumors or non-Hodgkin lymphoma (NHL). Part 2: Cohort Expansion. The primary objective of Part 2 of this study is to further evaluate the safety and tolerability of KB-0742 in defined participant cohorts including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC).

Relapsed Solid TumorsRefractory Solid TumorsNon-Hodgkin Lymphoma+2 more

Kronos Bio135 participantsStarted Feb 2021

Birmingham, Alabama, United States • Duarte, California, United States • Fountain Valley, California, United States +21 more locations

Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome

A Study of KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC)

Find Trials by Condition in Boston

Safety and Effectiveness of the MiniMed™ 780G System With DS5 CGM

Neuroblastoma Precision Trial

TAC T-cells for the Treatment of Claudin 18.2 Positive Solid Tumors (TACTIC-3)

Myeloma-Developing Regimens Using Genomics (MyDRUG)

Alcoholic Hepatitis Network Observational Study

Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery

Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women With Advanced Breast Cancer Which Progressed on or After Aromatase Inhibitor Treatment.

Psychological Response and Readiness Associated With OCD of the Knee

CGM-Assisted Management of PN

ATHN 7: Hemophilia Natural History Study

A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies

Identifying Oxytocin Deficiency in Adults With Pituitary Disease

Evaluation of SAR408701 in Patients With Advanced Solid Tumors

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination for the Treatment of Allergic Conjunctivitis

Rapid Normalization of Vitamin D Deficiency in PICU

Non-comparative Study of IFX-1 Alone or IFX-1+Pembrolizumab in Patients With Locally Advanced or Metastatic cSCC.

A Safety, Tolerability, and Efficacy Study of BMN 190 in Pediatric Patients < 18 Years of Age With CLN2 Disease