About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Vertical Soft Tissue Augmentation With CTG vs ADM | Clinical Trials | Clareo Health

Back to clinical trial search

RECRUITINGNANCT05729607

Vertical Soft Tissue Augmentation With CTG vs ADM

The study aims at comparing two different approaches for vertical soft tissue augmentation at implant sites exhibiting soft tissue dehiscences: autogenous connective tissue graft vs acellular dermal m...

Lead sponsor: Harvard Medical School (HMS and HSDM)•1 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Clareo turns complex medical information into clear understanding you can use.

Bring this clarity to your next appointment.

Keep all your medical notes and next steps in one place.

Start Free Trial

Contacts

Lorenzo Tavelli, DDS, MS

CONTACT

734-604-4364 lorenzo_tavelli@hsdm.harvard.edu

Sponsors

Lead Sponsor

Harvard Medical School (HMS and HSDM)

The present randomized clinical trial aims at investigating two approaches (autogenous connective tissue graft vs acellular dermal matrix + enamel matrix derivative) when performed for vertical soft tissue augmentation at sites with peri-implant soft tissue dehiscences. Clinical, volumetric, ultrasonographic, and patient-reported outcomes will be evaluated at different time points up to 1 year.

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Age ≥ 18 years
•Periodontally and systemically healthy
•Full-mouth plaque score and full-mouth bleeding score ≤ 20% (measured at four sites per tooth)
•Presence of single functional dental implant in the anterior with a PSTD
•Implants diagnosed as healthy (Berglundh et al., 2018)

Exclusion Criteria

•Contraindications for surgery
•Systemic condition (e.g. diabetes mellitus, HIV, cancer, etc) that could compromise wound healing
•Patients pregnant or attempting to get pregnant (self-reported)
•Untreated periodontitis
•Untreated peri-implant mucositis or peri-implantitis (Berglundh et al., 2018)
•Smoking, defined as self-reported daily habit. Occasional smokers won't be excluded
•History of soft tissue grafting at the implant site within the last 6 months

Related studies

Pediatric Orthopaedic Implant Safety & Efficacy

NCT05361980 · Fracture, Lengthening; Leg, and more

Improvement of Symptoms After Removal of the Essure® Contraceptive Implant

NCT06355713 · Implant Complication, Contraceptive Device; Complications

Clinical and Radiographic Evaluation of Immediate Implant Placement Using Osseodensification Versus Traditional Drilling Protocol

NCT06307691 · Implant Complication

Active Not RecruitingNA

Collagen Matrix + rhPDGF-BB vs Connective Tissue Graft for the Treatment of Peri-implant Soft Tissue Dehiscences

NCT05576922 · Implant Complication

Active Not RecruitingNA

Dental Implant Stability Placed in Healed Bony Sites Using Oversized Drilling Versus Conventional Drilling Protocol

NCT06917638 · Implant Complication

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 18, 2025Terms

Trial snapshot

StatusRECRUITING

PhaseNA

Enrollment28

Start dateMay 2023

Last updatedSep 18, 2025

Condition

Implant Complication

Locations shown

Harvard School of Dental Medicine

Boston, Massachusetts

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 18, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions