Clinical Trials in Boston

Showing 2481-2500 of 17,836 trials

PDT For Induction Therapy For Head And Neck Cancer

NCT07214987

This research study is being done to assess the safety and tolerability of toripalimab in combination with cisplatin and docetaxel (PDT) induction therapy for patients with CPS-positive locally advanced head and neck squamous cell carcinoma (HNSCC).

Squamous Cell CarcinomaHead and Neck Cancer Squamous Cell CarcinomaHead and Neck Cancer

Massachusetts General Hospital26 participantsStarted Mar 2026

Boston, Massachusetts, United States • Boston, Massachusetts, United States

Active Not RecruitingNA< 1 mile

VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone (VITAL)

NCT04573946

Vitamin D supplements are widely promoted for bone health. Both vitamin D and vitamin K are important for deposition of calcium in bone, but little is known about the relationship of vitamin K status and bone health.

Bone DensityBone HealthFractures

Brigham and Women's Hospital25,871 participantsStarted Jul 2019

Boston, Massachusetts, United States

COMPLETEDPhase 2< 1 mile

A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran (RO7198457) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Participants With Previously Untreated Advanced Melanoma.

NCT03815058

This study will evaluate the efficacy, safety, pharmacokinetics, and patient-reported outcomes (PROs) of autogene cevumeran (RO7198457) plus pembrolizumab compared with pembrolizumab alone in patients with previously untreated advanced melanoma.

Advanced Melanoma

Genentech, Inc.131 participantsStarted Dec 2018

Duarte, California, United States • La Jolla, California, United States • San Francisco, California, United States +38 more locations

PDT For Induction Therapy For Head And Neck Cancer

VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone (VITAL)

A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran (RO7198457) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Participants With Previously Untreated Advanced Melanoma.

Find Trials by Condition in Boston

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery

A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma

Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims Data

A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis (RRMS)

Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data

Improving Sleep With a Digital Cognitive Behavioral Therapy for Insomnia Application

Combination Chemotherapy With or Without Autologous Stem Cell Transplant in Treating Patients With Central Nervous System B-Cell Lymphoma

GDNF Gene Therapy for Multiple System Atrophy

A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma

Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)

Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy

EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines

Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation

Abbott Structural Heart Device Registry

Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis

Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Resectable Retroperitoneal Liposarcoma