Clinical Trials in Boston

Showing 2481-2500 of 17,836 trials

PDT For Induction Therapy For Head And Neck Cancer

NCT07214987

This research study is being done to assess the safety and tolerability of toripalimab in combination with cisplatin and docetaxel (PDT) induction therapy for patients with CPS-positive locally advanced head and neck squamous cell carcinoma (HNSCC).

Squamous Cell CarcinomaHead and Neck Cancer Squamous Cell CarcinomaHead and Neck Cancer

Massachusetts General Hospital26 participantsStarted Mar 2026

Boston, Massachusetts, United States • Boston, Massachusetts, United States

RECRUITINGNA< 1 mile

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

NCT05332639

The aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for Crohn's disease (PRE-Crohn's) tool on behaviors and biomarkers associated with risk for Crohn's disease in unaffected first-degree relatives of patients with inflammatory bowel disease. We hypothesize that personalized risk disclosure via the PRE-Crohn's educational tool is both feasible and successful in modifying behaviors associated with Crohn's disease risk and normalizing pre-clinical disease biomarkers when compared to standard Crohn's disease education. Broadly, completion of this project will also help elucidate the role of lifestyle and dietary factors in pre-clinical Crohn's disease development in high-risk individuals, and provide novel insight into potential strategies for disease prevention in this population.

Inflammatory Bowel DiseasesCrohn DiseaseCrohn Colitis+5 more

Massachusetts General Hospital80 participantsStarted Oct 2025

Boston, Massachusetts, United States

PDT For Induction Therapy For Head And Neck Cancer

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

Find Trials by Condition in Boston

A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran (RO7198457) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Participants With Previously Untreated Advanced Melanoma.

VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone (VITAL)

A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma

Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery

A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma

A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis (RRMS)

Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data

Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims Data

A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma

Improving Sleep With a Digital Cognitive Behavioral Therapy for Insomnia Application

GDNF Gene Therapy for Multiple System Atrophy

Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)

Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy

Combination Chemotherapy With or Without Autologous Stem Cell Transplant in Treating Patients With Central Nervous System B-Cell Lymphoma

EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines

Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation

Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis

Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Resectable Retroperitoneal Liposarcoma