Clinical Trials in Boston

Showing 2441-2460 of 17,836 trials

Resilient Families Feasibility Trial

NCT07383948

The goal of this study is to test the feasibility and acceptability of a dyadic, resiliency intervention ("Resilient Families;" R-FAM) that aims to reduce emotional distress and improve relationships among parents in the Neonatal Intensive Care Unit (NICU). To achieve this goal, the investigators are developing a randomized control trial where patients will be randomized to either the R-FAM condition or a minimally enhanced usual control (MEUC), which includes resources on parent mental health and coping in the NICU.

Parents

Massachusetts General Hospital50 participantsStarted Mar 2026

Boston, Massachusetts, United States

COMPLETEDPhase 3< 1 mile

Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)

NCT03867084

This study will evaluate the safety and efficacy of pembrolizumab (MK-3475) versus placebo as adjuvant therapy in participants with hepatocellular carcinoma (HCC) and complete radiological response after surgical resection or local ablation. The primary hypotheses of this study are that adjuvant pembrolizumab is superior to placebo with respect to: 1) recurrence-free survival (RFS) as assessed by blinded independent central review (BICR); and 2) overall survival (OS).

Hepatocellular Carcinoma

Merck Sharp & Dohme LLC959 participantsStarted May 2019

Gilbert, Arizona, United States • Tucson, Arizona, United States • Duarte, California, United States +246 more locations

Resilient Families Feasibility Trial

Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)

Find Trials by Condition in Boston

NeoVax Plus Ipilimumab in Renal Cell Carcinoma

COMPASSION S3 Post-Approval Study

Effects of Whole Fruit on Blood Sugar in People With Type 2 Diabetes

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

VIGOR: Virtual Genome Center for Infant Health

Low Dose IL-2 for the Treatment of Crohn's Disease

A Phase 2b Study of Zagociguat in Patients With MELAS

Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

Task-Shifting for Youth Suicide Prevention

Team Science (The Liver Health Study)

Microrandomized Trial to Optimize Use of Burden-reducing Self-monitoring Approaches in Behavioral Obesity Treatment

A Study to Find a Suitable Dose of BI 765883 and to Test Whether it Helps People With Advanced Pancreatic Cancer When Taken Alone or Together With Chemotherapy

A Study About How TAK-881 is Processed by the Body and Side Effects in People With Primary Immunodeficiency Diseases

A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer

Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib Treatment in a Novartis-sponsored Study

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer