Clinical Trials in Boston

Showing 2021-2040 of 8,503 trials

Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

NCT05850091

The goal of this double-blind randomized controlled trial is to determine how treatment with high intensity statin, low-dose colchicine, and their combination modulates progression and composition of coronary atherosclerosis in individuals with high polygenic risk for coronary artery disease.

Coronary Artery Disease

Massachusetts General Hospital200 participantsStarted Dec 2023

Boston, Massachusetts, United States

RECRUITINGPhase 2< 1 mile

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

NCT04900623

This research is being conducted to understand if treatment can be tailored for participants with HPV-related oropharynx cancers using both clinical features (stage of the tumor, smoking status) combined with an investigational HPV blood test. The names of the test and treatments involved in this study are: * NavDx® HPV ctDNA testing (HPV blood test) * Radiation therapy * Chemotherapy: Cisplatin, or Carboplatin and Paclitaxel (not all participants receive any or all of these agents)

HPV-Associated Oropharyngeal Squamous Cell CarcinomaHPV Positive Oropharyngeal Squamous Cell CarcinomaHPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Stage+9 more

Jonathan Schoenfeld, MD, MPH145 participantsStarted Jul 2021

Boston, Massachusetts, United States • Boston, Massachusetts, United States

Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

Find Trials by Condition in Boston

The Actuate-CBC Study

Texting to Reduce Human Immunodeficiency Virus (HIV) Risk

Jump: MR Simulation For Radiation Therapy Master Protocol

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis

Sequential Allocation Study of Music Duration

Prenatal Genetics Chatbot Trial: Prenatal GENEie

A Study to Evaluate Safety and Tolerability of CVL-231 (Emraclidine) in Adult Participants With Schizophrenia

Phase 3 Study to Evaluate the Safety and Efficacy of Hydrocortisone Acetate Suppositories

Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis

International CIPN Assessment and Validation Study

Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616) for Reversal of Neuromuscular Blockade in Pediatric Participants Aged Birth to <2 Years (MK-8616-169)

A Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery

A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED

A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)

A Study of Obexelimab in Patients With Systemic Lupus Erythematosus

Study Evaluating Food Effect and QTc in Patients With Advanced Malignancies

TURN-IT FOG: Improving Turning and Freezing of Gait in People With PD