Rheumatoid Arthritis Clinical Trials

Showing 13741-13760 of 47,334 trials

First Trimester Resistin Levels in HG

NCT06757374

This cross-sectional case-control study was conducted in Tuzla State Hospital Obstetrics Clinic in Turkey. The study evaluated 400 pregnant women during their first trimester of pregnancy. Many pregnant women (50-90%) experience nausea and vomiting during their first trimester; however, some patients have a disease called "hyperemesis gravidarum" (HG) characterized by very severe nausea and vomiting that may require hospitalization. resistin" is a peptide which is secreted primarily by human adipocytes and mononuclear cells. Evidence suggests that resistin increases plasma glucose concentration, reduces glucose intake by adipocytes, and promotes insulin resistance. Considering the HG effect on endocrinologic and metabolic complications, we hypothesized that resistin levels in maternal serum may change in the presence of HG; therefore, the aim of the present study was to evaluate these resistin levels during the first trimester and their correlation with HG severity.

Hyperemesis Gravidarum - SevereResistinGestational Diabetes Mellitus (GDM)

Dr. Lutfi Kirdar Kartal Training and Research Hospital210 participantsStarted Dec 2022

Kartal, Istanbul, Turkey (Türkiye)

Not Yet RecruitingPhase 1/2

Chidamide Plus Golidocitinib in Relapsed/Refractory Peripheral T-Cell Lymphoma

NCT06757387

This is a Phase I/II, open-label, single-arm study investigating the combination of chidamide and golidocitinib in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). The Phase I portion utilizes a 3+3 dose-escalation design to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of the drug combination. The Phase II portion will then evaluate the efficacy and safety of the RP2D in approximately 28 patients with relapsed or refractory PTCL. Treatment will continue until disease progression, unacceptable toxicity, withdrawal of consent, or meeting other stopping criteria. The primary goal of Phase I is to establish the safety and MTD and the RP2D. The primary goal of Phase II is to evaluate the treatment efficacy and safety of the combination at RP2D.

Peripheral T-cell Lymphoma

Peking University Cancer Hospital & Institute45 participantsStarted Dec 2024

First Trimester Resistin Levels in HG

Chidamide Plus Golidocitinib in Relapsed/Refractory Peripheral T-Cell Lymphoma

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