Effect of Clarithromycin on PK of Linaprazan, Linaprazan on PK of Clarithromycin and Linaprazan on PK of Midazolam

Exclusion Criteria

• •1. Have known allergies to any components of the linaprazan glurate formulation, to clarithromycin/midazolam or to any drugs of a similar class including excipients associated with any of the drugs.
• •2. Use of CYP3A4 inhibitors, antacids, PPIs or any medication that changes gastric pH.
• •3. Use of any prescribed or non-prescribed CYP3A4-inducing medication or other metabolic enzyme inducers.
• •4. History of any clinically significant disease or disorder defined in the protocol.