The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients with Compensated Cirrhosis

Exclusion Criteria

• •Active hepatocellular carcinoma (HCC) or remission of HCC within the past 3 months.
• •Untreated large esophageal varices (EV) greater than F2 or history of upper gastrointestinal bleeding from portal hypertension or gastric varices.
• •Active or history of hepatic encephalopathy (HE).
• •Inpatient hospitalization for any reason or discharge from the hospital within the past 3 months.
• •Complete portal vein thrombosis.
• •Transjugular intrahepatic portosystemic shunt.
• •Contraindications to exercise, such as recent myocardial infarction, unstable angina, electrocardiography changes within the past 24 hours, complete heart block, acute congestive heart failure, uncontrolled hypertension, hemoglobin level less than 11 g/dL, platelet count less than 50,000 cells/mm 3 .
• •End-stage renal disease without dialysis.
• •Severe orthopedic problems that limit the ability to exercise.
• •Inability to communicate with the research team via telemedicine system.
• •Body mass index (BMI) exceeding 35 kg/m 2 .
• •On alpha or beta-blocker