Multiple Sclerosis Clinical Trials

Showing 81-100 of 5,826 trials

A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

NCT06380816

This clinical trial is looking at UCB4594. This is the first time the drug is being tested in humans. UCB4594 is a type of drug called a monoclonal antibody. It has been designed to work by targeting a protein called human leucocyte antigen G (HLA-G) that is found in high levels on some cancer cells. By attaching itself to this protein it may help the immune system to attack and kill the cancer cells. The four main aims of the clinical trial are to find out: 1. The best dose of UCB4594 that can be given safely to participants in the trial. 2. What the side effects of UCB4594 are and how they can be managed. 3. What happens to UCB4594 inside the body and how it affects cancer cells. 4. Whether UCB4594 can cause cancer to shrink.

Advanced Solid TumoursSquamous Cell Carcinoma of Head and NeckCarcinoma, Non-Small-Cell Lung+8 more

Cancer Research UK167 participantsStarted Jul 2024

London, United Kingdom • Manchester, United Kingdom • Newcastle upon Tyne, United Kingdom +1 more locations

RECRUITINGPhase 3

A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer

NCT06919965

The main purpose of this study is to compare the disease-free survival (the length of time after randomization that a participant survives without any signs or symptoms of the cancer returning, or progressing) between Bacillus Calmette-Guérin (BCG) treated participants receiving treatment with TAR-210 versus investigator's choice of intravesical chemotherapy for treatment of high-risk non-muscle-invasive bladder cancer (HR-NMIBC).

Non-Muscle Invasive Bladder Neoplasms

Janssen Research & Development, LLC220 participantsStarted Sep 2025

Lakewood, Colorado, United States • Atlanta, Georgia, United States • Chicago Ridge, Illinois, United States +105 more locations

A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer

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