Kidney Disease Clinical Trials

Showing 581-600 of 1,850 trials

Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction

NCT04998227

The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).

Acute Coronary SyndromeAcute Coronary Syndrome With Renal Dysfunction

National Taiwan University Hospital300 participantsStarted Apr 2021

Taipei, Taiwan

RECRUITING

Molecular Mechanisms of Fibrillin/LTBP Superfamily in Renal Fibrosis and Cardiorenal Syndrome

NCT05012228

This project is to understand the LTBP4 expression in human renal fibrotic tissues. The investigators will exam major location of LTBP4 expression and check any similar or discrepancy in renal fibrosis with different etiologies.

Renal Fibrosis, CKD

National Taiwan University Hospital30 participantsStarted Jul 2021

Taipei, Taiwan

RECRUITING

Toxicokinetics of Protein-bound Uremic Toxins in ESRD Patients

NCT05755503

Protein-bound uremic toxins (PBUTs) are important uremic toxins, represented by indoxyl sulfate (IS), derived from the fermentation of dietary proteins by gut bacteria. The purpose of this study was to study the changes of IS in maintenance hemodialysis patients, and to construct a metabolic kinetics model of IS clearance. The model was then used to estimate the clearance rate of indoxyl sulfate by hemoperage, and to verify the application value of the model. This study intends to collect a series of serum, dialysate and urine samples from maintenance hemodialysis patients receiving high-throughput dialysis or hemodialysis filtration, so as to clarify the variation rule of IS during various blood purification treatments. Furthermore, a three-compartment model of dialysis IS metabolism kinetics was constructed according to the IS clearance of dialysis and residual kidney, and the above model was verified internally and externally. Finally, the model's fit and predictive value were validated in a group of MHD patients treated with HP without residual kidney.

Uremic; ToxemiaPharmacokineticsRenal Dialysis

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University100 participantsStarted Feb 2023

Shanghai, Shanghai Municipality, China

Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction

Molecular Mechanisms of Fibrillin/LTBP Superfamily in Renal Fibrosis and Cardiorenal Syndrome

Toxicokinetics of Protein-bound Uremic Toxins in ESRD Patients

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