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Extracellular Vesicles as Biomarkers for Chronic Renal Failure | Clinical Trials | Clareo Health

COMPLETEDNA

Extracellular Vesicles as Biomarkers for Chronic Renal Failure

NCT04700631•Centre Hospitalier Universitaire, Amiens

Summary

The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•subject \> 18 years old
•healthy subjects : no medical history, in particular cardiovascular, without drug treatment, without proteinuria, normal BMI
•CRF patients : eGFR estimated according to the MRDR formula less than 89 mL/min/1,73m²

Exclusion Criteria

•patients under dialysis protocols
•renal transplant patients

Locations (1)

CHU Amiens

Amiens, France

Key Dates

Start Date

January 1, 2021

Primary Completion Date

July 1, 2023

Completion Date

July 1, 2023

Last Updated

September 19, 2025

Enrollment

143

ACTUAL participants

Conditions

Chronic Renal FailureUrinary Extracellular Vesicle

Interventions

urinary extracellular vesicle concentration

DIAGNOSTIC_TEST

blood sample

DIAGNOSTIC_TEST

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RECRUITINGNA

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 19, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Extracellular Vesicles as Biomarkers for Chronic Renal Failure

Inclusion Criteria

Exclusion Criteria

A Clinical Study to Map the HLA Genomic Region in the Greek Population

Coronary Rotational Atherectomy Elective vs. Bailout in Severely Calcified Lesions and Chronic Renal Failure

Case Series : Management of Elevated Lipoprotein(a) Using Double-Filtration Plasmapheresis (DFPP) in Hemodialysis Patients With Chronic Kidney Disease ; ( LiPo-A )

Prediabetes in End Stage Renal Disease on Dialysis

The Effect of a Mobile Game Application on Children With CRF

A Study to Investigate the Effect of ASP1517 After Intermittent Oral Dosing in Dialysis Chronic Kidney Disease Patients With Anemia Compared With Darbepoetin as a Reference Drug