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Role of Corneal Nerves in Dry Eye Disease | Clinical Trials | Clareo Health

RECRUITING

Role of Corneal Nerves in Dry Eye Disease

Association Between Corneal Sensitivity, Nerve Morphology, Tear Film Homeostasis and Dry Eye Symptoms

NCT06841471•Daniela Nosch

Summary

This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss. Additionally, it seeks to investigate whether these factors vary based on the severity of dry eye symptoms.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Group with DED: Diagnosis of DED based on the TFOS DEWS II report
•Group without DED: No diagnosis of DED

Exclusion Criteria

•Systemic disease that may affect ocular health and innervation
•injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology
•regular application of systemic or ocular medication known to affect the tear film except from DED medications
•eye drops or makeup on the day of measurement.
•Remarks:
•Contact lens wearers are asked not to wear contact lenses for 1 week before the first appointment.
•Participant with DED medications will be asked to use only conservative-free eye drops on the days of examination

Locations (1)

Institute of Optometrym FHNW

Olten, Switzerland

Key Dates

Start Date

February 20, 2025

Primary Completion Date

December 1, 2025

Completion Date

December 1, 2025

Last Updated

March 11, 2025

Enrollment

140

ESTIMATED participants

Conditions

Dry Eye Disease (DED)Dry EyeDry Eye SensationCorneal Nerve

Contacts

Daniela S Nosch, BSc MSc PhD

CONTACT

41629572603 daniela.nosch@fhnw.ch

Emanuele Käser, BSc MSc

CONTACT

41629572302 emanuele.kaeser@fhnw.ch

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 11, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Role of Corneal Nerves in Dry Eye Disease

Inclusion Criteria

Exclusion Criteria

A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study

A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease.

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