A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study

Exclusion Criteria

• •Far best corrected visual acuity \< 1/10
• •Severe Dry Eye associated with:
• •* Eyelid malposition
• •* Stevens Johnson Syndrome
• •* Corneal dystrophy
• •* Ocular neoplasia
• •* Filamentous keratitis
• •* Corneal neovascularisation
• •* Orbital radiotherapy
• •* Dry eye related to Graft Versus Host Disease (GVHD)
• •History of any of the following within last 3 months:
• •* Systemic treatment of dry eye
• •* Systemic treatment of Meibomian Gland Dysfunction (MGD)
• •* Isotretinoïde,
• •* Cyclosporine,
• •* Tacrolimus, Siromilus, Pimecrolimus
• •* Punctual plugs
• •History of any of the following within previous six months:
• •* ocular trauma
• •* ocular infection, Ocular allergy
• •History of any of the following within last 12 months:
• •* inflammatory corneal ulcer
• •* Herpetic eye infection
• •* Uveitis
• •* Ocular surgery
• •Inability of patient to understand the investigation procedures and thus inability to give valid, informed consent.
• •Non-compliant patient (e.g. not willing to attend the follow-up visits, way of life interfering with compliance)
• •Participation in another clinical study or clinical investigation at the same time as the present investigation
• •Participation to the present clinical investigation during the exclusion period of another clinical study
• •Patient already included once in this clinical investigation
• •Patient under guardianship