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A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease. | Clinical Trials | Clareo Health

RECRUITING

A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease.

NCT07363824•Shanghai Changzheng Hospital

View on ClinicalTrials.gov

Summary

This study aims to see if the amount of iron in tears is linked to how severe dry eye disease is. We hope this can lead to a new way to help diagnose and understand dry eye. This is an observational study. We will compare tear samples from people with dry eye to samples from people with healthy eyes. We will measure the iron content in the tears and see if it correlates with standard dry eye test results and symptom scores.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Aged between 18 and 70 years, inclusive.
•Willing and able to provide written informed consent.

Exclusion Criteria

•History or clinical suspicion of significant systemic conditions: hematologic diseases, severe systemic infections, malignancies (treated or untreated), or chronic hepatic/renal insufficiency.
•Use of artificial tears or any topical eye drops within 2 hours prior to examination.
•Active ocular allergy, infection, or severe blepharitis within the past 1 month.
•Systemic or topical use of antibiotics, corticosteroids, NSAIDs, or immunosuppressants within the past 1 month.
•History of contact lens wear within the past 1 month.
•History of blood transfusion, ocular surgery, or significant ocular trauma within the past 6 months.
•Women who are pregnant, breastfeeding, or postmenopausal women undergoing hormone replacement therapy.
•Known hypersensitivity to fluorescein sodium.

Locations (1)

Changzheng Hospital

Shanghai, China

Key Dates

Start Date

February 6, 2026

Primary Completion Date

May 1, 2029

Completion Date

May 1, 2029

Last Updated

February 10, 2026

Enrollment

ESTIMATED participants

Conditions

Dry Eye DiseaseIron

Interventions

Diagnostic tear fluid collection and ocular surface evaluation

PROCEDURE

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RECRUITINGPHASE3

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 10, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease.

Inclusion Criteria

Exclusion Criteria

Turkish Validity and Reliability Study of PRevention of Toxic Chemicals in the Environment for Children Tool

Comparing High and Low Dose Iron Treatments for People on Peritoneal Dialysis: The PALaDIN Study

A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye

Leveraging Regulatory Flexibility for Methadone Take-Home Dosing to Improve Retention in Treatment for Opioid Use Disorder

Kids With Iron Deficiency and Scoliosis