Post-operative Intravenous Iron to Treat Iron-deficiency Anemia in Patients Undergoing Cardiac Surgery

Exclusion Criteria

• •1. specialized procedures (e.g., ventricular assist device insertion, thoracoabdominal aneurysm, complex adult congenital surgery and heart transplant)
• •2. established contraindications to IV iron:
• •1. hypersensitivity to the iron product
• •2. history of \>2 food and/or drug allergic reactions (excluding drug intolerance)
• •3. non-iron deficiency anemias such as myelodysplastic syndrome
• •4. history of iron overload or disturbances in use of iron such as hemochromatosis or hemosiderosis
• •5. decompensated liver cirrhosis (MELD ≥ 19) or active hepatitis
• •6. active infection
• •3. preoperative unstable hemodynamics defined as the requirement for vasopressors or inotropes, or active bleeding (as noted in the clinical record and/or defined as a requirement for red blood cell transfusion for ongoing clinical bleeding)
• •4. refusal of blood products for religious or other reasons
• •5. known pregnancy
• •6. already enrolled in this trial
• •7. enrolment in another interventional trial which may impact anemia or transfusion management (for example, a trial of hemostatic therapies, such as tranexamic acid)
• •8. receipt of intravenous iron at any point in the 6 weeks prior to randomization