Long-term Outcomes Sub-Study of Preoperative Combined Iron Therapy

Exclusion Criteria

• •1. Contraindications for the administration of iron sucrose, ascorbic acid, or rHuEPO.
• •2. Presence of a temperature exceeding 37.5 °C or the utilization of non-prophylactic antibiotics.
• •3. Individuals with a weight equal to or less than 50kg.
• •4. Individuals with a family history of haemochromatosis or thalassaemia, or those with a transferrin saturation level exceeding 50% or a documented history of iron overload.
• •5. Presence of other known haematological disorders such as folic acid or vitamin B12 deficiency, haemolytic anaemia, haemoglobinopathies, iron granulocytic anaemia, G6PD deficiency, etc.
• •6. Requirement for emergency surgical intervention.
• •7. Severe hepatic or renal impairment, ALT \>3 times the upper limit of normal value or AST \>3 times the upper limit of normal value, creatinine \>1.5 times the upper limit of normal value
• •8. Pregnant or lactating women
• •9. history of blood transfusion, intravenous iron or ascorbic acid use within 12 weeks prior to surgery
• •10. Acute blood loss, gastrointestinal bleeding, etc. in the preoperative period.