A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine

Exclusion Criteria

• •Emergency surgery situation
• •Anemia - hemoglobin \<10 g/dL
• •Clinical signs of systemic infection or other infection requiring anti-infective treatment (viral, bacterial, fungal, parasitic; single-dose prophylaxis allowed)
• •Systemic immunosuppressive or anti-inflammatory treatment including corticosteroids \>10 mg prednisolone equivalent/day
• •Any anti-cancer treatment within 3 months (e.g. immunotherapy, chemotherapy, radiotherapy)
• •Major surgery within 2 months
• •AKI within the last month
• •Prior renal transplants or RRT
• •Planned use of contrast media within 5 days prior to surgery or during surgery
• •Patient included in an interventional clinical trial involving a pharmacological intervention
• •Any reason that would make participation unadvisable, at the discretion of the investigator.
• •Autoimmune disorders such as anti-glomerular basement membrane (anti-GBM) diseases, systemic lupus erythematosus, chronic rheumatic heart diseases, acute rheumatic heart pericarditis, endocarditis, myocarditis, rheumatic mitral valve diseases, rheumatic aortic valve diseases